Basic information Safety Supplier Related

Hydrocortisone IMpurity I

Basic information Safety Supplier Related

Hydrocortisone IMpurity I Basic information

Product Name:
Hydrocortisone IMpurity I
Synonyms:
  • Hydrocortisone IMpurity I
  • 11β,14,17,21-tetrahydroxypregn-4-ene-3,20-dione
  • Hydrocortisone EP Impurity I
  • Hydrocortisone impurity I (EP)
  • Hydrocortisone Impurity 9(Hydrocortisone EP Impurity I)
  • Pregn-4-ene-3,20-dione, 11,14,17,21-tetrahydroxy-, (11β)-
  • 14α-Hydroxyhydrocortisone
  • (8R,9S,10R,11S,13S,14R,17R)-11,14,17-Trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one (Hydrocortisone Impurity)
CAS:
103795-84-2
MF:
C21H30O6
MW:
378.46
Mol File:
103795-84-2.mol
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Hydrocortisone IMpurity I Chemical Properties

Melting point:
241-242 °C
Boiling point:
602.3±55.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
pka
12.10±0.70(Predicted)
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Hydrocortisone IMpurity I Usage And Synthesis

Uses

14α-Hydroxycortisol (Hydrocortisone EP Impurity I) is an impurity of Hydrocortisone (H714615), a topical corticosteroid (1), but more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland (2). Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.

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