BroModifluoroMethyl phenyl sulfone Chemical Properties

Melting point:

33-34 °C

Boiling point:

291.8±40.0 °C(Predicted)

Density 

1.745±0.06 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Chloroform (Sparingly), DMSO (Slightly)

form 

Solid

color 

White to Off-White

Safety Information

Safety Statements 

24/25

HS Code 

29309090

BroModifluoroMethyl phenyl sulfone Usage And Synthesis

Description

The nucleophilic reactions of bromodifluoromethyl phenyl sulfone with electrophiles such as aldehydes in the presence of TDAE affords (phenylsulfonyl)difluoromethyl-containing synthetically useful intermediates. Palladium-mediated reactions of styrene derivatives, vinyl ethers, and heteroaromatics with bromodifluoromethyl phenyl sulfone in the presence of potassium carbonate affords the (phenylsulfonyl)difluoromethylated products.

Uses

Bromodifluoromethyl phenyl sulfone is an intermediate component in the synthesis of (phenylsulfonyl)difluoromethyl and can be used to prepare (phenylsulfonyl)difluoromethylated products by palladium-mediated reactions.

Uses

Bromodifluoromethyl Phenyl Sulfone can be used to prepare difluoromethyl ethers via difluoromethylation of alcohols.

Reactions

(1) Difluoromethylation of aldehydes.

(2) Difluoromethylation of styrenes, vinyl ethers, and heteroaromatics.

References

[1] G.K. SURYA PRAKASH . Nucleophilic difluoromethylation and difluoromethylenation using bromodifluoromethyl phenyl sulfone[J]. Journal of Fluorine Chemistry, 2005. DOI:10.1016/j.jfluchem.2005.07.011.
[2] NAKIN SURAPANICH. ChemInform Abstract: Palladium-Mediated Heck-Type Reactions of [(Bromodifluoromethyl)sulfonyl]benzene: Synthesis of α-Alkenyl- and α-Heteroaryl-Substituted α,α-Difluoromethyl Phenyl Sulfones.[J]. ChemInform, 2013. DOI:10.1002/chin.201314090.

BroModifluoroMethyl phenyl sulfone(80351-58-2)Related Product Information

• Difluoromethyl 2-pyridyl sulfone
• Difluoromethyl phenyl sulfone
• Fluoromethyl phenyl sulfone
• FluoroMethyl 2-pyridyl sulfone