Fluoromethyl phenyl sulfone Chemical Properties

Melting point:

53 °C

Boiling point:

151 °C(Press: 0.3 Torr)

Density 

1.274±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

soluble in Methanol

form 

powder to crystal

color 

White to Almost white

Safety Information

Safety Statements 

24/25

HS Code 

29309090

Fluoromethyl phenyl sulfone Usage And Synthesis

Description

Fluoromethyl phenyl sulfone is a useful nucleophilic monofluoromethylation reagent for the synthesis of fluoromethyl alcohols and amines. In the nucleophilic reaction step, strong bases such as LiHMDS and n-BuLi are used to generate the nucleophilic (phenylsulfonyl)fluoromethyl anion. In the desulfonylation step, sodium/mercury amalgam and magnesium are the commonly used reductive reagents. Besides, the addition reaction between fluoromethyl phenyl sulfone and carbonyls can be used to prepare monofluoroaklenes via acylation–elimination.

Uses

Fluoromethyl phenyl sulfone can be used to prepare monofluoroaklenes and chiral α-Monofluoromethyl Amines. Highly stereoselective nucleophilic monofluoromethylation of (R)-(tert-butanesulfinyl)imines with fluoromethyl phenyl sulfone was achieved to afford α-monofluoromethylamines with a nonchelation-controlled stereoselectivity mode. By using the same chemistry, (R)-(tert-butanesulfinyl)imines bearing a terminal tosylate (OTs) group can be converted to α-monofluoromethylated cyclic secondary amines with high stereoselectivity.

Reactions

(1) Monofluoromethylation of aldehydes and ketones.

(2) Monofluoromethylation of aldimines and ketimines.

(3) Monofluoromethylenation of aldehydes and ketones.

(4) (Phenylsulfonyl)fluoromethylation of esters.

References

[1] YA LI. Stereoselective Nucleophilic Monofluoromethylation of N-(tert-Butanesulfinyl)imines with Fluoromethyl Phenyl Sulfone[J]. Organic Letters, 2006. DOI:10.1021/ol060322t.
[2] M. INBASEKARAN. ChemInform Abstract: A NOVEL AND EFFICIENT SYNTHESIS OF FLUOROMETHYL PHENYL SULFONE AND ITS USE AS A FLUOROMETHYL WITTIG EQUIVALENT[J]. ChemInform, 1985. DOI:10.1002/chin.198536160.
[3] GOUVERNEUR V, LOZANO ó. Preparation of Chiral α-Monofluoromethyl Amines Using Fluoromethyl Phenyl Sulfone[C]. 1900. DOI:10.1055/sos-SD-203-00578.

Fluoromethyl phenyl sulfone(20808-12-2)Related Product Information

• PHENYL VALERATE
• Chlorodimethylphenylsilane
• Dimethyl sulfoxide
• Trimethylphenylammonium chloride
• Dimethyl sulfone
• Tetradifon
• Methyltriphenylphosphonium bromide
• PHENYL RESIN
• Phenylacetic acid
• 2-NITRO-4-(TRIFLUOROMETHYLSULFONYL)ANILINE
• 4-(TRIFLUOROMETHYLSULFONYL)ANILINE
• 2-CHLORO-5-(TRIFLUOROMETHYLSULFONYL)ANILINE
• 4-(TRIFLUOROMETHYLSULFONYL)CHLOBENZENE
• 4-(DIFLUOROMETHYLSULFONYL)NITROBENZENE
• 4-(DIFLUOROMETHYLSULFONYL)CHLOROBENZENE
• Phenyl (trifluoromethyl) sulfone
• 4-CHLOROPHENYL 2-CHLORO-1,1,2-TRIFLUOROETHYL SULFONE
• 1-CHLORO-2-NITRO-4-TRIFLUOROMETHANESULFONYL-BENZENE