ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > LDN-27219
LDN-27219
LDN-27219 Basic information
- Product Name:
- LDN-27219
- Synonyms:
-
- CS-1194
- LDN-27219 (LDN 27219
- 184663
- LDN-27219
- 2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-acetic acid hydrazide
- 2-((4-oxo-3,5-diphenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetohydrazide
- Acetic acid, 2-[(3,4-dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-, hydrazide
- LDN-27219 >=98% (HPLC)
- CAS:
- 312946-37-5
- MF:
- C20H16N4O2S2
- MW:
- 408.5
- EINECS:
- 604-604-1
- Mol File:
- 312946-37-5.mol
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LDN-27219 Chemical Properties
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble15mg/mL, clear
- form
- powder
- pka
- 11.87±0.37(Predicted)
- color
- white to beige
- InChI
- 1S/C20H16N4O2S2/c21-23-16(25)12-28-20-22-18-17(15(11-27-18)13-7-3-1-4-8-13)19(26)24(20)14-9-5-2-6-10-14/h1-11H,12,21H2,(H,23,25)
- InChIKey
- WLBUICQBNZXIDJ-UHFFFAOYSA-N
- SMILES
- [s]1c2nc([n]([c](c2c(c1)c4ccccc4)=O)c3ccccc3)SCC(=O)NN
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LDN-27219 Usage And Synthesis
Uses
LDN 27219 is a transglutaminase inhibitor.
Biological Activity
LDN-27219 is a revesible inhibitor of transglutaminase 2 (TG2) th at binds to the GTP binidng site of the enzyme and inhbits activity with and IC50 of 600 nM.', 'LDN-27219 is a thieno[2,3-d]pyrimidine-4-one-acylhydrazide derivative. Closed conformation of TG2 induced by LDN-27219 can be a potential therapeutic strategy for age-related vascular dysfunction and lowering blood pressure.
in vivo
LDN-27219 (0.1-2 mg/kg; i.v. once) affects vivo arterial pressure and shows larger effects on older rats[2].
| Animal Model: | 12 to 14-week-old male Wistar rats[2] |
| Dosage: | 0.1, 1 and 2 mg/kg |
| Administration: | Intravenous injection; 0.1, 1 and 2 mg/kg once |
| Result: | Dose-dependently decreased mean arterial pressure of mice. |
| Animal Model: | 12 to 14- and 35 to 40-week-old male Wistar rats |
| Dosage: | 0.1, 1 and 2 mg/kg |
| Administration: | Intravenous injection; 0.1, 1 and 2 mg/kg once |
| Result: | Decreased mean arterial pressure in old group more significant than young group. |
storage
Store at +4°C
LDN-27219Supplier
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070 13913916777;
- info@chemlin.com.cn
ChemShuttle, Inc.
- Tel
- 0510-83588313-811 18800520310
- sales@chemshuttle.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
Bide Pharmatech Ltd.
- Tel
- 400-400-164-7117 18317119277
- product02@bidepharm.com
SPIRO PHARMA
- Tel
- eric_feng1954@126.com