ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > Skp2 Inhibitor C1
Skp2 Inhibitor C1
Skp2 Inhibitor C1 Basic information
- Product Name:
- Skp2 Inhibitor C1
- Synonyms:
-
- 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid
- CS-1230
- kp2 Inhibitor C1
- Skp2-IN-C1
- Skp2 Inhibitor C1
- SKPin C1
- Skp2 inhibitor C1 (SKPin C1)
- MDK-1699
- CAS:
- 432001-69-9
- MF:
- C18H13BrN2O4S2
- MW:
- 465.34
- Mol File:
- 432001-69-9.mol
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Skp2 Inhibitor C1 Chemical Properties
- Boiling point:
- 655.3±65.0 °C(Predicted)
- Density
- 1.74±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 10 mg/mL
- form
- A crystalline solid
- pka
- 2.97±0.10(Predicted)
- color
- White to yellow
- InChI
- 1S/C18H13BrN2O4S2/c19-13-3-4-14(25-10-16(22)23)12(6-13)7-15-17(24)21(18(26)27-15)9-11-2-1-5-20-8-11/h1-8H,9-10H2,(H,22,23)/b15-7-
- InChIKey
- IYCJJVVXEHZJHE-CHHVJCJISA-N
- SMILES
- S1\C(=C/c3c(ccc(c3)Br)OCC(=O)O)\C(=O)N(C1=S)Cc2cnccc2
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Skp2 Inhibitor C1 Usage And Synthesis
Uses
SKPin C1 is a small molecule Skp-2-mediated p27 degradation inhibitor.
Biological Activity
Cell permeable: yes', 'Primary Target
disrupts p27-Skp2 interaction', 'Reversible: yes
in vivo
Skp2 Inhibitor C1 (5 mg/kg and 10 mg/kg; 3 times within 24 h: 24, 5, and 1 h before the test) shows the antidepressant-like effect in mouse models following chronic treatment by using the tail suspension test (TST), forced swimming test (FST), and social interaction test (SIT)[2].
Skp2 Inhibitor C1Supplier
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
Guangzhou Isun Pharmaceutical Co., Ltd
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
Bide Pharmatech Ltd.
- Tel
- 400-400-164-7117 18317119277
- product02@bidepharm.com
LETOPHARM LIMITED
- Tel
- +86-21-5821 5861
- sales@letopharm.com