(DEAMINO-CYS1,BETA-CYCLOHEXYL-ALA4,ARG8)-VASOPRESSIN Chemical Properties

storage temp. 

Store at RT

form 

Solid

color 

White to off-white

Water Solubility 

Soluble to 1 mg/ml in Water

Sequence

{Mpa}-Tyr-Phe-{Cha}-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge:Mpa1-Cys6)

(DEAMINO-CYS1,BETA-CYCLOHEXYL-ALA4,ARG8)-VASOPRESSIN Usage And Synthesis

Uses

d[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors[1][2].

References

[1] Ling Ling Cheng, et al. Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem. 2004 Apr 22;47(9):2375-88. DOI:10.1021/jm030611c
[2] Cristiana Griffante, et al. Selectivity of d[Cha4]AVP and SSR149415 at human vasopressin and oxytocin receptors: evidence that SSR149415 is a mixed vasopressin V1b/oxytocin receptor antagonist. Br J Pharmacol. 2005 Nov;146(5):744-51. DOI:10.1038/sj.bjp.0706383

(DEAMINO-CYS1,BETA-CYCLOHEXYL-ALA4,ARG8)-VASOPRESSIN(500170-27-4)Related Product Information

• LCAT
• 3-MERCAPTOPROPIONYL-BETA-3-PYRIDYL-D-ALA-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2
• 3-MERCAPTO-3-METHYL-BUTYRYL-TYR(ME)-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2
• 3-MERCAPTOPROPIONYL-TYR-PHE-GLN-ASN-CYS-PRO-LYS-GLY-NH2, (DISULFIDE BOND)
• D[LEU4,LYS8]-VP
• 3-MERCAPTO-3-METHYL-BUTYRYL-TYR-PHE-VAL-ASN-CYS-PRO-D-ARG-GLY-NH2
• Desmopressin
• (DEAMINO-CYS1,D-ORN8)-VASOPRESSIN
• (DEAMINO-CYS1,VAL4,D-ARG8)-VASOPRESSIN
• (DEAMINO-CYS1,BETA-CYCLOHEXYL-ALA4,ARG8)-VASOPRESSIN