Diisobutylamine Chemical Properties

Melting point:

-77 °C (lit.)

Boiling point:

137-139 °C (lit.)

Density 

0.74 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.4081(lit.)

Flash point:

85 °F

storage temp. 

Flammables area

solubility 

insoluble to slightly soluble in water; soluble in ethanol, methanol, ethyl ether, ethyl acetate, acetone, benzene, aromatic and aliphatic hydrocarbons, fixed oils, mineral oil, oleic and stearic acids

pka

11.07±0.28(Predicted)

form 

Liquid

color 

Clear

Odor

amine odor

Water Solubility 

5 g/L (20 ºC)

Sensitive 

Air Sensitive

BRN 

1209251

Dielectric constant

2.7（22℃）

LogP

2.383 (est)

CAS DataBase Reference

110-96-3(CAS DataBase Reference)

NIST Chemistry Reference

1-Propanamine, 2-methyl-N-(2-methylpropyl)-(110-96-3)

EPA Substance Registry System

Diisobutylamine (110-96-3)

Safety Information

Hazard Codes 

C

Risk Statements 

10-22-34-52/53

Safety Statements 

26-36/37/39-45-25-16-61

RIDADR 

UN 2361 3/PG 3

WGK Germany 

1

RTECS 

TX1750000

F 

34

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29211990

Hazardous Substances Data

110-96-3(Hazardous Substances Data)

MSDS

• Language:English Provider:Diisobutylamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Diisobutylamine Usage And Synthesis

Chemical Properties

The chemical reactivity of diisobutylamine is similar to other aliphatic amines and is governed by the unshared electron pair on the nitrogen atom. It is a strong base tending to form salts with acids. As with other secondary amines, diisobutylamine can be nitrosated, especially under acidic conditions, by nitrite ion or by nitrogen oxides from the air to form the carcinogenic and mutagenic N-nitrosodiisobutylamine (Olah et al 1975).

Uses

Diisobutylamine was used to study the effect of achiral amine on hydrogenation of ethyl pyruvate over cinchonidine-Pt/Al2O3 catalyst system. Diisobutylamine is the principal starting material for the herbicide Butylate (Zeneca).

Production Methods

Diisobutylamine can be produced by the reaction of ammonia and butanol over a dehydration catalyst at high temperature and pressure (Hawley 1977). Alternatively, ammonia, butanol, and hydrogen can be passed over a dehydrogenation catalyst. In 1976, 18,000 tons of diisobutylamine were produced (Schweizer et al 1978). Diisobutylamine is also naturally present in foods and soil.
As with other secondary amines, diisobutylamine can be nitrosated to form the highly toxic (Olah 1975) N-nitrosodiisobutylamine (Guttenplan 1987; Vlasenko et al 1981; Spiegeholder et al 1978). Thus, nitrosation of commercial preparations of diisobutylamine occurs on standing, presumably by reaction with nitrogen oxides in the air (Spiegelhalder et al 1978) and N-nitrosodiisobutylamine has been found in various fishery products (Kawabata et al 1974) and other foods (Osborne 1972; Telling 1972).

General Description

Diisobutylamine appears as a clear colorless liquid with an ammonia-like odor. Insoluble in water and less dense than water. Hence floats on water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.

Air & Water Reactions

Highly flammable. Sensitive to heat and air. Insoluble in water.

Reactivity Profile

Diisobutylamine can react vigorously with oxidizing materials . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

Inhalation of high concentrations of vapor will cause irritation of the respiratory tract and the lungs. Contact with liquid may result in severe skin and eye irritation. Exposure to concentrated vapors may result in corneal edema. Poisonous if swallowed.

Health Hazard

Diisobutylamine is a relatively strong base and is therefore irritating to the eyes, respiratory tract, and skin. Inhalation of vapors can result in pulmonary edema following prolonged exposure. Ingestion of liquid can cause severe burning of the esophagus.

Industrial uses

Diisobutylamine is used as a chemical intermediate in the manufacture of several agricultural and pharmaceutical products.

Safety Profile

Poison by ingestion. A dangerous fire hazard when exposed to heator flame; can react vigorously with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of Nox

Metabolism

There is little information available on the metabolism of diisobutylamine.

Diisobutylamine(110-96-3)Related Product Information

• Hexetidine
• Bis(2-ethylhexyl)amine
• 2-Chloro-N,N-bis(2-methylpropyl)acetamide
• Diisobutylamine
• SOLASODINE
• SOLASONINE
• VERATRINE
• TRIS(2-ETHYLHEXYL)AMINE
• TOMATINE
• 2,2′-Azobis(2-methylpropionamidine) dihydrochloride
• DIISOBUTYLAMINE HYDROCHLORIDE
• Octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine oxide
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• ISOBUTANE
• N,N-DIISOBUTYLETHYLENEDIAMINE
• AMO 1618