(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE
(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE Basic information
- Product Name:
- (N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE
- Synonyms:
-
- (4S)-3-[(E)-BUT-2-ENOYL]-4-BENZYL-2-OXAZOLIDINONE
- (S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDINONE
- (N-CROTONYL)-(4S)-BENZYL-2-OXAZOLIDINONE
- (N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE
- UIC-1005
- (R)-4-BENZYL-3-CROTONYL-2-OXAZOLIDINONE
- (4S)-N-Crotonyl-4-benzyl-2-oxazolidinone, 99%
- (N-Crotonyl)-(R)-4-benzyl-2-oxazolidinone
- CAS:
- 90719-30-5
- MF:
- C14H15NO3
- MW:
- 245.27
- Product Categories:
-
- Peptide
- Mol File:
- 90719-30-5.mol
(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE Chemical Properties
- Melting point:
- 84-88 °C(lit.)
- Boiling point:
- 351.0±25.0 °C(Predicted)
- Density
- 1.205±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥30mg/mL
- pka
- -1?+-.0.40(Predicted)
- form
- powder
- color
- white to off-white
Safety Information
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29349990
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE Usage And Synthesis
Uses
Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin can be used to synthesize chemical probes toward PEBP-proteins. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3].
Biochem/physiol Actions
Locostatin is a cell permeable, potent inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.
in vivo
Locostatin (0.5 mg/kg; i.p.; once a day for 7 days) aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice[3].
| Animal Model: | 6 weeks, 18-22 g, male ICR mice (TAA model; injected intraperitoneally with 300 mg/kg TAA once a day for 2 days)[3] |
| Dosage: | 0.5 mg/kg |
| Administration: | I.p.; once a day for 7 days |
| Result: | Decreased the expression of RKIP, led to more severe damage, such as steatosis and hepatic lesions, increased the production of ROS in the liver and TNF-α, IL-6 and IL-1β in the sera of mice with acute liver injury, inhibitd Nrf2 and HO-1 expression in the livers of mice, induced NF-κB activation in the livers of mice,increased the phosphorylation of JNK, p38 and ERK in liver tissues. |
References
[1] Beshir AB, et al. Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket. For Immunopathol Dis Therap. 2011;2(1):47-58. DOI:10.1615/forumimmundisther.v2.i1.60
[2] Mc Henry KT, et al. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. Chembiochem. 2002 Nov 4;3(11):1105-11. DOI:10.1002/1439-7633(20021104)3:11<1105::AID-CBIC1105>3.0.CO;2-S
[3] Lin X, et al. Inhibition of RKIP aggravates thioacetamide-induced acute liver failure in mice. Exp Ther Med. 2018 Oct;16(4):2992-2998. DOI:10.3892/etm.2018.6542
(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONESupplier
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 4006356688 18621169109
- market03@meryer.com
- Tel
- 800-810-5118
- cnchemical@thermofisher.com
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Tel
- 021-65675885 18964387627
- info@efebio.com
(N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE(90719-30-5)Related Product Information
- Crotonic acid
- (R)-4-Benzyl-2-oxazolidinone
- (N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE
- N-CROTONYL-(4R)-ISOPROPYL 2-OXAZOLIDINONE
- (N-CROTONYL)-(4S)-ISOPROPYL-2-OXAZOLIDINONE
- 3-[(E)-2-BUTENOYL]-1,3-OXAZOLIDIN-2-ONE
- N-(ISOBUTOXYMETHYL)ACRYLAMIDE
- (N-ACETYL)-(4R)-BENZYL-2-OXAZOLIDINONE
- 3-ACRYLOYL-2-OXAZOLIDINONE
- Phenprobamate
- (S)-4-Benzyl-2-oxazolidinone