Serine/threonine-protein kinase D1 Chemical Properties

storage temp. 

-20°C

form 

buffered aqueous solution

biological source

rabbit

Safety Information

WGK Germany 

nwg

Storage Class

10 - Combustible liquids

Serine/threonine-protein kinase D1 Usage And Synthesis

Uses

Anti-PKD1 antibody produced in rabbit has been used in western blot analysis(1:500).

Biological Activity

Polycystic kidney disease 1/polycystin-1 (PKD1/PC1) plays a regulatory role in cell migration and cell proliferation through mammalian targets of rapamycin (mTOR) and Janus kinase (JAK) signals. PKD1 inhibits cell migration and in some situations, acts as a tumor suppressor protein in the lung cancer cell line (A549). Before birth, polycystin-1 is the most active protein in kidney cells, and it interacts and works with polycystin-2 (PKD2). Mutations in the PKD1 gene are responsible for 85 percent of polycystic kidney diseases (PKDs).