CYM 50260 Chemical Properties

Boiling point:

469.4±45.0 °C(Predicted)

Density 

1.407±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

<35.06mg/ml in DMSO

pka

-3.50±0.10(Predicted)

form 

Solid

color 

White to off-white

CYM 50260 Usage And Synthesis

Uses

CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonist with an EC50 of 45 nM. CYM50260 displays no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R[1].

storage

Store at -20°C

References

[1] Guerrero M, et al. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P-R) agonists. Bioorg Med Chem Lett. 2012 Jan 1;22(1):537-42. DOI:10.1016/j.bmcl.2011.10.096
[2] Onuma T, et al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb Res. 2017 Aug;156:91-100. DOI:10.1016/j.thromres.2017.06.001