ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Basic information
- Product Name:
- N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
- Synonyms:
-
- N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
- PIM447 (LGH447)
- PIM447
- PIM447 (LGH447) Free Base
- EOS-60671
- 2-Pyridinecarboxamide, N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-
- CAS:
- 1210608-43-7
- MF:
- C24H23F3N4O
- MW:
- 440.46
- Mol File:
- 1210608-43-7.mol
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N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Chemical Properties
- Boiling point:
- 493.7±45.0 °C(Predicted)
- Density
- 1.290±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:88.0(Max Conc. mg/mL);199.79(Max Conc. mM)
Ethanol:88.0(Max Conc. mg/mL);199.79(Max Conc. mM) - form
- Solid
- pka
- 1.35±0.70(Predicted)
- color
- White to off-white
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N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Usage And Synthesis
Uses
PIM kinases promote growth and survival of tumor cells and are expressed in a wide variety of human cancers. These kinases are potential therapeutic targets. PIM447 is a PIM kinase inhibitor.
in vivo
PIM447 (100 mg/kg; p.o.; 5 times for a week) reduces tumor burden[2].
| Animal Model: | 6-week-old female NOD-SCID-IL-2Rγ/(NSG) mice (bearing RPMI-8226-luc cells)[2] |
| Dosage: | 100 mg/kg |
| Administration: | p.o.; 5 times for a week |
| Result: | Clearly controlled tumor progression as measured by bioluminescence. |
IC 50
PIM1; PIM2; PIM3
N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamideSupplier
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