Basic information Safety Supplier Related

ITX-5061 HCl

Basic information Safety Supplier Related

ITX-5061 HCl Basic information

Product Name:
ITX-5061 HCl
Synonyms:
  • ITX-5061 HCl
  • ITX-5061
  • ITX-5061 hydrochloride (ITX5061)
  • ITX-5061 hydrochloride
  • ITX506 HCl
  • N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride , ITX5061
  • N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride
CAS:
1252679-52-9
MF:
C30H38ClN3O7S
MW:
620.16
Mol File:
1252679-52-9.mol
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ITX-5061 HCl Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 83.3 mg/mL (134.32 mM)
form 
Solid
color 
Light yellow to light brown
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Safety Information

HS Code 
2933998090
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ITX-5061 HCl Usage And Synthesis

Uses

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).

in vivo

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1). Treatment of ITX5061 (30 mg/kg/day) for mice results in a 50% increase in HDL-C levels compare to baseline. ApoA-I levels are moderately (+15 %) but significantly increased in ITX5061-treated HuAITg mice, compare to mice receive vehicle. ITX5061 significantly decreases HDL-CE catabolism with an FCR of 1.86±0.40 pools/d vs 2.47±0.26 pools/d in the control group (P<0.05), while calculated production rates are identical in both groups (129±24 μg/g/d vs 129±16 μg/g/d). Moreover, accumulation of [3H] CE in the liver is significantly lower in ITX5061-treated mice indicating that increased HDL-CE levels are due to reduced uptake by the liver[1].

References

[1] Masson D, et al. Increased HDL cholesterol and apoA-I in humans and mice treated with a novel SR-BI inhibitor. Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2054-60. DOI:10.1161/ATVBAHA.109.191320

ITX-5061 HClSupplier

ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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2853530910@QQ.com
Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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Sales@ATKchemical.com
Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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psaitong@jm-bio.com
Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com