1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide
1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Basic information
- Product Name:
- 1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide
- Synonyms:
-
- 1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide
- PF-04745637
- 1-(4-Chlorophenyl)- N-[2-[4-hydroxy-4-(trifluoromethyl)-1-piperidinyl]-3-phenylpropyl]cyclopentanecarboxamide
- PF 4745637
- PF4745637
- PF-4745637
- PF-04746537
- PF04745637,Inhibitor,bowel,TRPA1,disease,inhibit,respiratory,PF-04745637,Transient receptor potential channels,inflammatory,TRP Channel,skin
- CAS:
- 1917294-46-2
- MF:
- C27H32ClF3N2O2
- MW:
- 509.0033896
- Mol File:
- 1917294-46-2.mol
More
Less
1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Chemical Properties
- Boiling point:
- 651.8±55.0 °C(Predicted)
- Density
- 1.281±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- pka
- 12.14±0.20(Predicted)
- form
- Solid
- color
- White to off-white
More
Less
1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Usage And Synthesis
Biological Activity
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1]. Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1].
References
[1]. Laurie B. Schenkel, et al. The discovery of a potent series of carboxamide TRPA1 antagonists. J. Med. Chem. 2016, 59, 6, 2794-2809.
1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamideSupplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696,15000506266 15000506266
ShangHai Angti Biotechnology Co., Ltd.
- Tel
- 13764913901
- info@angtibio.com
ATK CHEMICAL COMPANY LIMITED
- Tel
- 3429815786 13301662590
- sales@atkchemical.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai Chaolan Chemical Technology Center
- Tel
- QQ:65489617 15618227136
- info@SuperLan-chem.com