TUG-905
TUG-905 Basic information
- Product Name:
- TUG-905
- Synonyms:
-
- TUG-905
- Benzenepropanoic acid, 2-fluoro-4-[[[2'-methyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methyl]amino]-
- TUG905,TUG 905
- CAS:
- 1390641-90-3
- MF:
- C27H30FNO5S
- MW:
- 499.59
- Mol File:
- 1390641-90-3.mol
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TUG-905 Chemical Properties
- Boiling point:
- 718.2±60.0 °C(Predicted)
- Density
- 1.268±0.06 g/cm3(Predicted)
- pka
- 4.76±0.10(Predicted)
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TUG-905 Usage And Synthesis
Uses
TUG-905 is a potent GPR40 agonist with an pEC50 value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression[1][2].
in vivo
TUG-905 (2.0 μL, 1.0 mM; i.c.v.; twice a day for 6 days) reduces body mass and exhibited a trend toward reducing caloric intake[1].
| Animal Model: | 6 weeks, Male Swiss mice[1] |
| Dosage: | 2.0 μL, 1.0 mM |
| Administration: | I.c.v.; twice a day for 6 days |
| Result: | Reduced body mass and exhibited a trend toward reducing caloric intake, and induced an increase of IL10 and IL6 in the hypothalamus, and increased the POMC mRNA expression. |
References
[1] Dragano NRV, et al. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation. J Neuroinflammation. 2017 Apr 26;14(1):91. DOI:10.1186/s12974-017-0869-7
[2] Engel DF, et al. Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms. Sci Rep. 2020 Jul 6;10(1):11047. DOI:10.1038/s41598-020-68110-2