NSC232003 Chemical Properties

Density 

1.60±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Water : 17 mg/mL (100.51 mM);DMSO : < 1 mg/mL (insoluble or slightly soluble)

form 

Solid

pka

9.32±0.20(Predicted)

color 

White to off-white

NSC232003 Usage And Synthesis

Uses

NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level.

References

[1] Myrianthopoulos V, et al. Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation. Eur J Med Chem. 2016 May 23;114:390-6. DOI:10.1016/j.ejmech.2016.02.043

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