Basic information Safety Supplier Related

SUVN-D4010

Basic information Safety Supplier Related

SUVN-D4010 Basic information

Product Name:
SUVN-D4010
Synonyms:
  • SUVN-D4010
  • SUVN-1004028
  • SUVN-D1003019
  • SUVN-D-1208045
  • Usmarapride free base
  • SUVN-D4010/ Usmarapride
  • 1H-Indazole, 3-[5-[1-(3-methoxypropyl)-4-piperidinyl]-1,3,4-oxadiazol-2-yl]-1-(1-methylethyl)-
CAS:
1428862-32-1
MF:
C21H29N5O2
MW:
383.49
Mol File:
1428862-32-1.mol
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SUVN-D4010 Chemical Properties

Boiling point:
541.9±60.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
form 
Solid
pka
7.84±0.10(Predicted)
color 
Off-white to light yellow
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SUVN-D4010 Usage And Synthesis

Uses

Usmarapride (SUVN-D4010) free base is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM). Usmarapride (SUVN-D4010) free base can be used for the research of cognitive deficits associated with Alzheimer's disease[1].

in vivo

Usmarapride (SUVN-D4010) (1-3 mg/kg; p.o.; Male Wistar rats 10-12 weeks old) free base attenuates the long-term memory deficits in object recognition test (ORT)[1].
Usmarapride (1, 3, and 10 mg/kg; p.o.) free base significantly reverses the scopolamine-induced amnesia[1].
Usmarapride free base shows a statistically significant effect at 3.0 mg/kg on both exploration time and recognition index[1].
Usmarapride (SUVN-D4010) free base shows good oral exposures, good bioavailability, and good brain exposures in rats[1].

IC 50

5-HT4 Receptor: 44 nM (EC50)

References

[1] Nirogi R, et al. Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010): A Potent, Selective 5-HT4 Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer's Disease. J Med Chem. 2021;64(15):10641-10665. DOI:10.1021/acs.jmedchem.1c00703

SUVN-D4010Supplier

Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-025-66113011 18626450290
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cb5@aikonchem.com
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
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021-59167510 18117107507
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TargetMol Chemicals Inc.
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15002134094
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+1-781-999-5354;
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