t-Butoxycarbonyl-PEG2-sulfonic acid Chemical Properties

Density 

1.218±0.06 g/cm3(Predicted)

pka

1.34±0.50(Predicted)

t-Butoxycarbonyl-PEG2-sulfonic acid Usage And Synthesis

Description

t-Butoxycarbonyl-PEG2-sulfonic acid is a PEG linker containing a t-Boc protecting group and sulfonic acid moiety. The t-Boc protecting group can be removed under acidic conditions. The sulfonic acid can undergo esterification, halogenation and displacement reactions. The hydrophilic PEG linkers increase the water solubility of a compound in aqueous conditions.

Uses

Boc-PEG2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005