3-(4-pyridinyl)-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazole 3-(Pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole Chemical Properties

storage temp. 

2-8°C

solubility 

DMSO: 2mg/mL, clear (warmed)

form 

powder

color 

white to light brown

3-(4-pyridinyl)-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazole 3-(Pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole Usage And Synthesis

Description

YU142670 is a novel selective inhibitor against OCRL1/INPP5F and OCRL2/INPP5B by targeting OCRL catalytic domain.

Uses

YU142670 is an inhibitor of OCRL/INPP5B with IC50 values of 0.71 μM and 1.78 μM respectively[1].

References

[1] Mills SJ, et al. Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family. Biochemistry. 2016 Mar 8;55(9):1384-97. DOI:10.1021/acs.biochem.5b00838