1A-116
1A-116 Basic information
- Product Name:
- 1A-116
- Synonyms:
-
- 1A-116
- 1A-116; 1A 116; 1A116;1430208-73-3
- Guanidine, N-(3,5-dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-
- TIAM1,inhibit,1A 116,Ras,Rho GTPases,EGF,Apoptosis,1A-116,circadian rhythms,1A116,Inhibitor
- 1-(3,5-Dimethylphenyl)-3-(2-(trifluoromethyl)phenyl)guanidine , 1A-116
- 1-(3,5-Dimethylphenyl)-3-(2-(trifluoromethyl)phenyl)guanidine
- 1A-116, 10 mM in DMSO
- N-(3,5-Dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-guanidine
- CAS:
- 1430208-73-3
- MF:
- C16H16F3N3
- MW:
- 307.31
- Product Categories:
-
- API
- Mol File:
- 1430208-73-3.mol
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1A-116 Chemical Properties
- Boiling point:
- 357.5±52.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (325.40 mM);Water : < 0.1 mg/mL (insoluble)
- form
- Solid
- pka
- 9.78±0.10(Predicted)
- color
- White to off-white
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1A-116 Usage And Synthesis
Uses
A1-116 is a novel specific Rac1 inhibitor.
in vivo
1A-116 (3 mg/kg; i.v.; once a day for 21 days) demonstrates a high antimetastatic activity with about 60% formation reduction of total metastatic lung colonies in vivo and shows no apparent toxicity[1].
?
1A-116 (20 mg/kg; i.p.; once a day, 73 days for ZT12, 68 days for ZT3) increases survival time when treated at ZT12 compare to ZT3 in tumor-bearing mice. (ZT: Zeitgeber time 12 (ZT12) defined as the time of lights off (local time 7 p.m.) and ZT0 defined as lights on (local time 7 a.m.))[2].
?
1A-116 shows good oral availability[3].
| Animal Model: | Female BALB/c inbred mice (8 to 10-week-old; average 20 g)[1] |
| Dosage: | 3 mg/kg |
| Administration: | Intravenous injection; once a day for 21 days. |
| Result: | Demonstrated a high antimetastatic activity. |
| Animal Model: | Male NIH Swiss foxN1(?/?) nude mice (2-month-old; GBM model)[2]. |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection (at ZT3, ZT12); once a day, 73 days for ZT12, 68 days for ZT3. |
| Result: | Increased survival time when treated at ZT12 compared to ZT3 in tumor-bearing mice. |
storage
Store at -20°C
1A-116Supplier
Sichuan Wei Keqi Biological Technology Co., Ltd.
- Tel
- 028-81700200 18116577057
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Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
- info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com