Basic information Safety Supplier Related

PD 404182

Basic information Safety Supplier Related

PD 404182 Basic information

Product Name:
PD 404182
Synonyms:
  • 6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE
  • PD 404,182
  • 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
  • 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
  • 3,4-Dihydro-2H,6H-benzo[e]pyrimido[1,2-c][1,3]thiazin-6-imine
  • 2H,6H-Pyrimido[1,2-c][1,3]benzothiazin-6-imine, 3,4-dihydro-
CAS:
72596-74-8
MF:
C11H11N3S
MW:
217.29
Mol File:
Mol File
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PD 404182 Chemical Properties

Boiling point:
366.8±25.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥22 mg/mL, soluble
pka
6.27±0.20(Predicted)
form 
powder
color 
Light yellow to yellow
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3

MSDS

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PD 404182 Usage And Synthesis

Uses

PD 404182 is an inhibitor of SARS-CoV-2

Enzyme inhibitor

This KDO-8-P synthase inhibitor and potential antibiotic (FW = 217.29 g/mol), also named 6H-6-imino(2,3,4,5-tetrahydropyrimido)[1,2-c][1,3] benzothiazine, is a slow, tight-binding agent that targets 3-deoxy-D-mannooctulosonate-8-phosphate synthase, an enzyme participating in the synthesis of 3-deoxy-D-manno-2-octulosonic acid (KDO). The latter is an essential component of LPS (lipopolysaccharide) in the outer membrane of Gramnegative bacteria. PD 404182 is an antiretroviral agent with submicromolarinhibitory activity against human immunodeficiency virus-1 (HIV-1) and HIV-2 infection. PD-404182 also potently inhibits dimethylarginine dimethylaminohydrolase isoform-1 (DDAH1), the human enzyme that degrades Asymmetric Dimethylarginine, or ADMA (See Asymmetric Dimethylarginine). Because ADMA inhibits nitric oxide synthesis and because ADMA levels are predictive for future cardiovascular disease, chronic use of PD-404182 is apt to have side-effects.

PD 404182Supplier

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