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NORDIHYDROCAPSAICIN

Basic information Safety Supplier Related

NORDIHYDROCAPSAICIN Basic information

Product Name:
NORDIHYDROCAPSAICIN
Synonyms:
  • Octanamide,N-[(4-hydroxy-3-methoxyphenyl)methyl]-7-methyl-
  • NORDIHYDROCAPSAICIN
  • N-[(4-Hydroxy-3-methoxyphenyl)methyl]-7-methyl-octanamide
  • Norhydrocapsaicin
  • N-(4-Hydroxy-3-methoxybenzyl)-7-methyloctanamide
  • Nordihydrocapsaic
  • NORDIHYDROCAPSAICIN USP/EP/BP
  • Nordihydrocapsaicin-RM
CAS:
28789-35-7
MF:
C17H27NO3
MW:
293.4
Product Categories:
  • Miscellaneous Natural Products
Mol File:
28789-35-7.mol
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NORDIHYDROCAPSAICIN Chemical Properties

Boiling point:
487.0±35.0 °C(Predicted)
Density 
1.036±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
2-8°C
solubility 
Chloroform: soluble; DMSO: soluble
form 
A crystalline solid
pka
9.76±0.20(Predicted)
color 
Light brown to gray
InChI
InChI=1S/C17H27NO3/c1-13(2)7-5-4-6-8-17(20)18-12-14-9-10-15(19)16(11-14)21-3/h9-11,13,19H,4-8,12H2,1-3H3,(H,18,20)
InChIKey
VQEONGKQWIFHMN-UHFFFAOYSA-N
SMILES
C(NCC1=CC=C(O)C(OC)=C1)(=O)CCCCCC(C)C
LogP
3.046 (est)
EPA Substance Registry System
Nordihydrocapsaicin (28789-35-7)
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Safety Information

HS Code 
2939800000
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NORDIHYDROCAPSAICIN Usage And Synthesis

Uses

Nordihydrocapsaicin is a capsaicinoid and analog and congener of capsaicin in chili peppers.

Definition

ChEBI: Nordihydrocapsaicin is a member of methoxybenzenes and a member of phenols.

in vivo

Nordihydrocapsaicin (0.1-0.2% CAPs (10 mg/kg BW), p.o., daily for 8 weeks) prevents low-fat-high carbohydrate diet and high-fat diet-induced obesity by regulating the NADPH oxidase and Nrf2 pathways in rats[4].

Animal Model:Wistar rats [4]
Dosage:0.1%–0.2% CAPs (10 mg/kg BW)
Administration:p.o., daily for 8 weeks
Result:Caused a 32% and 37% reduction for HSD and 16% and 18% reduction for HFD in serum and liver MDA concentrations and elevation in serum TAC by 163% and 54% in the HSD- and HFD-fed rats (P<0.001), respectively.

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