CGP 20712 A Chemical Properties

storage temp. 

2-8°C

solubility 

H₂O: 10 mg/mL

form 

solid

color 

white

Water Solubility 

H2O: >10mg/mL
DMSO: 100mg/mL

Safety Information

WGK Germany 

3

CGP 20712 A Usage And Synthesis

Uses

CGP-20712A methanesulfonate salt has been used as a β1-adrenergic receptor antagonist in adult rat ventricular myocytes (ARVM) and rat cardiac fibroblasts. It may also be used as an antagonist for the β1-adrenergic receptor in rat bladder smooth muscles.

Biological Activity

Highly selective and potent β 1 -adrenoceptor antagonist (IC 50 = 0.7 nM). Displays 10,000-fold selectivity over β 2 -adrenoceptors. Also available as part of the β -Adrenoceptor Antagonist Tocriset™ .

Biochem/physiol Actions

CGP-20712A methanesulfonate salt is a selective β1-adrenoceptor antagonist.

in vitro

In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.

in vivo

Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection.

CGP 20712 A (105737-62-0)Related Product Information

• 2-Methyl-4-trifluoromethylimidazole
• CGP 20712 A
• 1-(2-HYDROXY-ETHYLAMINO)-3-PHENOXY-PROPAN-2-OL
• 4-(Trifluoromethyl)-1H-imidazole
• 2-Phenyl-4-(trifluoromethyl)-1H-imidazole
• 2-(4-ETHOXY-PHENYL)-1H-IMIDAZOLE