CGP 20712 A

Product Name: CGP 20712 A
CAS No.: 105737-62-0
Chemical Name: CGP 20712 A
Synonyms: CGP207122HCl;CGP 20712 mesylate;CGP 20712 DIHYDROCHLORIDE;CGP-20712A methanesulfonate salt;CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE;CGP-20712A methanesulfonate salt solid, >=98% (HPLC);1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd;1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate;1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE;(+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate
CBNumber: CB4380786
Molecular Formula: C24H29F3N4O8S
Formula Weight: 590.57
MOL File: 105737-62-0.mol

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CGP 20712 A Property

storage temp.: 2-8°C
solubility: H₂O: 10 mg/mL
form: solid
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C231
Product name: CGP-20712A methanesulfonate salt
Purity: solid, ≥98% (HPLC)
Packaging: 10mg
Price: $195.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: C231
Product name: CGP-20712A methanesulfonate salt
Purity: solid, ≥98% (HPLC)
Packaging: 50mg
Price: $1270
Updated: 2023/01/07

Tocris

Product number: 1024
Product name: CGP20712dihydrochloride
Purity: ≥96%(HPLC)
Packaging: 50
Price: $936
Updated: 2021/12/16

Tocris

Product number: 1024
Product name: CGP20712dihydrochloride
Purity: ≥96%(HPLC)
Packaging: 10
Price: $227
Updated: 2021/12/16

Usbiological

Product number: 254932
Product name: CGP 20712 dihydrochloride
Packaging: 10mg
Price: $480
Updated: 2021/12/16

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CGP 20712 A Chemical Properties,Usage,Production

Uses

CGP-20712A methanesulfonate salt has been used as a β1-adrenergic receptor antagonist in adult rat ventricular myocytes (ARVM) and rat cardiac fibroblasts. It may also be used as an antagonist for the β1-adrenergic receptor in rat bladder smooth muscles.

Biological Activity

Highly selective and potent β 1 -adrenoceptor antagonist (IC 50 = 0.7 nM). Displays 10,000-fold selectivity over β 2 -adrenoceptors. Also available as part of the β -Adrenoceptor Antagonist Tocriset™ .

Biochem/physiol Actions

CGP-20712A methanesulfonate salt is a selective β1-adrenoceptor antagonist.

in vitro

In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.

in vivo

Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection.

CGP 20712 A Preparation Products And Raw materials

Raw materials

Preparation Products

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CGP 20712 A Suppliers

China 8 Germany 2 South Korea 1 Switzerland 1 United Kingdom 1 United States 6 Global 19

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10658
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9414
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 9946
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 29778
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24023
Advantage: 58

105737-62-0, CGP 20712 A Related Search:

2-Methyl-4-trifluoromethylimidazole CGP 20712 A 1-(2-HYDROXY-ETHYLAMINO)-3-PHENOXY-PROPAN-2-OL 4-(Trifluoromethyl)-1H-imidazole 2-Phenyl-4-(trifluoromethyl)-1H-imidazole 2-(4-ETHOXY-PHENYL)-1H-IMIDAZOLE

CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE

1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd

CGP207122HCl

CGP-20712A methanesulfonate salt

(±)-2-Hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy]propyl] amino]ethoxy]-benzamide methanesulfonate salt

1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE

CGP 20712 DIHYDROCHLORIDE

(+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate

CGP 20712 mesylate

1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate

CGP-20712A methanesulfonate salt solid, >=98% (HPLC)

105737-62-0

C23H25F3N4O5CH4O3S

C24H27F3N4O7S

C23H25F3N4O52HCl

Adrenoceptor