4-(Trifluoromethyl)-1H-imidazole

Product Name: 4-(Trifluoromethyl)-1H-imidazole
CAS No.: 33468-69-8
Chemical Name: 4-(Trifluoromethyl)-1H-imidazole
Synonyms: 4-TrifluoroMethyliMidazole;EOS-60687;4(5)-(Trifluoromethyl)imidazole;4-(TRIFLUOROMETHYL)-1H-IMIDAZOLE;1H-Imidazole, 5-(trifluoromethyl)-;4-(TRIFLUOROMETHYL)-1H-IMIDAZOLE(I);4-(Trifluoromethyl)-1H-imidazole 98%
CBNumber: CB8763109
Molecular Formula: C4H3F3N2
Formula Weight: 136.08
MOL File: 33468-69-8.mol

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4-(Trifluoromethyl)-1H-imidazole Property

Melting point:: 149-150
Boiling point:: 224.7±35.0 °C(Predicted)
Density: 1.440±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 10.29±0.10(Predicted)
form: Solid
color: White to Almost white
InChI: InChI=1S/C4H3F3N2/c5-4(6,7)3-1-8-2-9-3/h1-2H,(H,8,9)
InChIKey: DFLGRTIPTPCKPJ-UHFFFAOYSA-N
SMILES: C1NC(C(F)(F)F)=CN=1

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38-40
Safety Statements: 26-36/37-24/25
Hazard Note: Irritant
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS005796
Product name: 4-(Trifluoromethyl)-1H-imidazole
Purity: AldrichCPR
Packaging: 100MG
Price: $68.1
Updated: 2023/06/20

TCI Chemical

Product number: T2928
Product name: 4(5)-(Trifluoromethyl)imidazole
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $191
Updated: 2025/07/31

TRC

Product number: T790645
Product name: 4-Trifluoromethyl-1H-imidazole
Packaging: 10g
Price: $395
Updated: 2021/12/16

Apolloscientific

Product number: PC9869
Product name: 4-(Trifluoromethyl)-1H-imidazole
Purity: 98%
Packaging: 1g
Price: $19
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-3-88
Product name: 4-(Trifluoromethyl)-1H-imidazole
Purity: 97%
Packaging: 1g
Price: $33
Updated: 2021/12/16

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4-(Trifluoromethyl)-1H-imidazole Chemical Properties,Usage,Production

Chemical Properties

Off-white crystalline powder

Uses

4-Trifluoromethyl-1H-imidazole acts as an inhibitor of sweet almond β-glucosidase. It is used as a reagent used in the synthesis of 3-substituted 2-aminopyridines via displacement of 3-fluoro-2-nitropyridine.

Synthesis

431-35-6

77287-34-4

33468-69-8

Procedure for the synthesis of 4-(trifluoromethyl)-1H-imidazole: 3-bromo-1,1,1-trifluoropropan-2-one (25.0 g, 131 mmol, Aldrich Item No. 374059) and formamide (104 mL, 2.62 mol) were sequentially added to a 500 mL round bottom flask. The reaction mixture was slowly heated to reflux temperature (about 140 °C) and kept at reflux for 2.5 hours of reaction. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with 200 mL of 10% aqueous K2CO3 solution and subsequently extracted with ether (5 x 200 mL). The organic phases were combined, washed sequentially with 10% aqueous K2CO3 (2 x 100 mL) and deionized water (2 x 100 mL), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure to give a brown solid. The resulting solid was washed with dichloromethane (DCM) to finalize 4-(trifluoromethyl)-1H-imidazole (4.0 g, 22% yield) as a brown solid. The structure of the product was confirmed by 1H NMR (CD3OD): δ 7.82 (s, 1H), 7.60 (s, 1H).

References

[1] Patent: WO2010/83246, 2010, A1. Location in patent: Page/Page column 100

4-(Trifluoromethyl)-1H-imidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(Trifluoromethyl)-1H-imidazole Suppliers

China 133 India 4 Japan 1 United Kingdom 1 United States 13 Global 152

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View Lastest Price from 4-(Trifluoromethyl)-1H-imidazole manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 4-(Trifluoromethyl)-1H-imidazole 33468-69-8
Price: US $500.00-190.00/g
Min. Order: 5g
Purity: 99%
Supply Ability: 50
Release date: 2024-07-12

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(Trifluoromethyl)-1H-imidazole 33468-69-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-14

Career Henan Chemical Co

Product: 4-(Trifluoromethyl)-1H-imidazole 33468-69-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-24

33468-69-8, 4-(Trifluoromethyl)-1H-imidazoleRelated Search:

2-(TRIFLUOROMETHYL)IMIDAZOL[1,2-A]PYRAZINE CGP 20712 A 2-(3-chlorophenyl)-4-(trifluoromethyl)-1H-imidazole 5-TRIFLUOROMETHYL-1H-BENZOIMIDAZOLE-2-CARBOXYLICACID 2-(3-Pyridinyl)-4-(trifluoromethyl)-1H-imidazole 5-AMINO-2-(TRIFLUOROMETHYL)BENZIMIDAZOLE 2-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)-1H-IMIDAZOLE 2-(2-Pyridyl)-4-trifluoromethylimidazole 2-Chloro-6-(trifluoromethyl)-1H-benzimidazole 2,4-DIBROMO-5-(TRIFLUOROMETHYL)-1H-IMIDAZOLE Trifluoromethyl(1H-imidazole-1-yl) ketone 2-phenyl-4-(trifluoromethyl)-1H-imidazole 2-(4-Methylphenyl)-4-(trifluoromethyl)-1H-imidazole,2-p-tolyl-4-(trifluoromethyl)-1H-imidazole 2-methyl-4-(trifluoromethyl)-1H-imidazole 4-BROMO-6-(TRIFLUOROMETHYL)BENZIMIDAZOLE (2-TRIFLUOROMETHYL-BENZOIMIDAZOL-1-YL)-ACETIC ACID 4-CHLORO-2-FLUORO-5-METHYLBENZENESULFONYL CHLORIDE 2-(Trifluoromethyl)benzimidazole

4(5)-(Trifluoromethyl)imidazole

4-TrifluoroMethyliMidazole

1H-Imidazole, 5-(trifluoromethyl)-

EOS-60687

4-(TRIFLUOROMETHYL)-1H-IMIDAZOLE(I)

4-(TRIFLUOROMETHYL)-1H-IMIDAZOLE

4-(Trifluoromethyl)-1H-imidazole 98%

33468-69-8

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