2-Chloro-6-(trifluoromethyl)-1H-benzimidazole
- Product Name
- 2-Chloro-6-(trifluoromethyl)-1H-benzimidazole
- CAS No.
- 86604-86-6
- Chemical Name
- 2-Chloro-6-(trifluoromethyl)-1H-benzimidazole
- Synonyms
- -Chloro-6-(trifluoromethyl)benzimidazole;2-Chloro-6-(trifluoroMethyl)benziMidazole;2-CHLORO-5-(TRIFLUOROMETHYL)BENZIMIDAZOLE;2-CHLORO-6-TRIFLUOROMETHYL-1H-BENZIMIDAZOLE;1H-BenziMidazole, 2-chloro-6-(trifluoroMethyl)-;2-chloro-6-(trifluoromethyl)-1H-1,3-benzodiazole;2-chloro-5-(trifluoroMethyl)-1H-1,3-benzodiazole;2-chloro-6-(trifluoromethyl)-1H-benzo[d]imidazole;2-chloro-5-(trifluoromethyl)-1H-benzo[d]imidazole
- CBNumber
- CB9238501
- Molecular Formula
- C8H4ClF3N2
- Formula Weight
- 220.58
- MOL File
- 86604-86-6.mol
2-Chloro-6-(trifluoromethyl)-1H-benzimidazole Property
- Melting point:
- 186-188 °C
- Boiling point:
- 322.1±52.0 °C(Predicted)
- Density
- 1.569±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.75±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C381648
- Product name
- 2-Chloro-6-(trifluoromethyl)-1H-benzimidazole
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C381648
- Product name
- 2-Chloro-6-(trifluoromethyl)-1H-benzimidazole
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC105607
- Product name
- 2-chloro-6-(trifluoromethyl)-1h-benzimidazole
- Packaging
- 10g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FC105607
- Product name
- 2-chloro-6-(trifluoromethyl)-1h-benzimidazole
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- W8893
- Product name
- 2-Chloro-5-(trifluoromethyl)benzimidazole
- Packaging
- 1g
- Price
- $173
- Updated
- 2021/12/16
2-Chloro-6-(trifluoromethyl)-1H-benzimidazole Chemical Properties,Usage,Production
Uses
2-Chloro-6-(trifluoromethyl)-1H-benzimidazole is a useful reagent in preparing chiral 2-aminobenzimidazoles as recoverable organocatalyst.
Synthesis
133687-93-1
86604-86-6
General procedure for the synthesis of 2-chloro-6-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one from 5-(trifluoromethyl)-1H-benzimidazole: 1. Preparation of Intermediate 1: 5-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one (Intermediate 2, 3.76 g, 18.6 mmol) was mixed with phosphorus trichloride (56 mL) and reacted at 95 °C for 18 h. The reaction was carried out at 95 °C for 1 hour. 2. Post-treatment: After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was washed with toluene (3 x 30 mL) and evaporated to dryness at 50 °C. 3. Purification: The resulting solid was recrystallized with ethyl acetate (EtOAc). The precipitate was collected by filtration, washed with ether (Et2O) and dried to give 2-chloro-6-(trifluoromethyl)-1H-benzimidazole (3.75 g, 17.0 mmol, 91% yield). 4. Characterization: 1H-NMR (400 MHz, DMSO-d6): δ 7.90 (1H, s), 7.72 (1H, d), 7.56 (1H, dd); UPLC-MS: retention time 0.67 min, m/z 221 [M + H]+.
References
[1] Patent: WO2008/129007, 2008, A1. Location in patent: Page/Page column 28-29
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 15, p. 7188 - 7211
[3] European Journal of Medicinal Chemistry, 2008, vol. 43, # 7, p. 1390 - 1402
[4] Patent: US2003/36652, 2003, A1
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 18, p. 5010 - 5014
2-Chloro-6-(trifluoromethyl)-1H-benzimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-6-(trifluoromethyl)-1H-benzimidazole manufacturers
- Product
- 2-Chloro-6-(trifluoromethyl)-1H-benzimidazole 86604-86-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07