SALOR-INT L224693-1EA Chemical Properties

Boiling point:

533.7±50.0 °C(Predicted)

Density 

1.562±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO:64.34(Max Conc. mg/mL);147.09(Max Conc. mM)

form 

powder (flocculent)

pka

10.24±0.70(Predicted)

color 

white to beige

InChI

1S/C19H11F4N3OS2/c20-9-3-5-10(6-4-9)25-17(27)16-15(24)14-11(19(21,22)23)8-12(26-18(14)29-16)13-2-1-7-28-13/h1-8H,24H2,(H,25,27)

InChIKey

ZATJMMZPGVDUOM-UHFFFAOYSA-N

SMILES

NC1=C(C(NC2=CC=C(F)C=C2)=O)SC3=C1C(C(F)(F)F)=CC(C4=CC=CS4)=N3

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

SALOR-INT L224693-1EA Usage And Synthesis

Uses

FDI-6 is an inhibitor of FOXM1. FDI-6 binds directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation.

Biochem/physiol Actions

Forkhead domain inhibitor-6 (FDI-6) is used to treat anaemia patients because of diminished red blood production. In Hep-2 cells, FDI-6 can stimulate cell death and also helps to prevent cell proliferation, invasion and migration.

References

[1] Gormally MV, et al. Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun. 2014 Nov 12;5:5165. DOI:10.1038/ncomms6165

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• SALOR-INT L224693-1EA