2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE Chemical Properties

Melting point:

169-171 °C(lit.)

Boiling point:

389.8±17.0 °C(Predicted)

Density 

1.389±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

3.95±0.10(Predicted)

form 

Powder

color 

White to off-white

λmax

232nm(phosphate buffer sol.)(lit.)

BRN 

153889

LogP

3.411 (est)

CAS DataBase Reference

2103-99-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38

Safety Statements 

26-36-36/37/39

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

XJ1026732

HazardClass 

IRRITANT

PackingGroup 

III

HS Code 

29341000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

2-Amino-4-(4-chlorophenyl)thiazole was used in the preparation of 2-chloroacetamido-4-(4-chlorophenyl)thiazole.

Synthesis

GENERAL METHOD: A mixture of thiourea (1.2 mmol) and α-bromo-4-chloroacetophenone (1 mmol) in ethanol (2 mL) was stirred and reacted at 70 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature, poured into ice water, filtered to collect the precipitate precipitated, and dried to obtain the target product 2-amino-4-(4-chlorophenyl)thiazole. The product yields and physical properties were as follows: [6a (99% yield), white solid, melting point 150-152 °C (literature value 26: 149-150 °C); 6b (100% yield), white solid, melting point 162-165 °C (literature value 26: 163-164 °C); 6c (0.236 g, 93% yield), white solid, melting point 179-181 °C (literature value 26: 180-181 °C); 6d (98% yield), white solid, melting point 203.6-204.2 °C (literature value 28/22: 204.0-204.5 °C); 6e (94% yield), bright yellow solid, melting point 287-288 °C (literature values 26,27: 285-286 °C); 6f (100% yield), white solid, melting point 172-174°C (literature values 29-31: 172°C).

References

[1] Arkivoc, 2018, vol. 2018, # 7, p. 110 - 118
[2] Chinese Chemical Letters, 2014, vol. 25, # 1, p. 172 - 175
[3] Research on Chemical Intermediates, 2015, vol. 41, # 11, p. 8099 - 8109
[4] Molecules, 2017, vol. 22, # 5,
[5] Synthetic Communications, 2009, vol. 39, # 16, p. 2895 - 2906

2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE(2103-99-3)Related Product Information

• 2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE
• 2-Amino-5-(4-chlorophenyl)thiazole
• ETHYL 2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE-5-CARBOXYLATE
• Ethyl 2-amino-5-(4-chlorophenyl)thiazole-4-carboxylate
• Ethyl 2-amino-5-(3-chlorophenyl)thiazole-4-carboxylate
• Methyl 2-amino-4-(3-chlorophenyl)thiazole-5-carboxylate
• 2-CHLORO-N-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]ACETAMIDE
• N-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]-2-PIPERIDINOACETAMIDE
• Methyl 2-amino-4-(4-chlorophenyl)thiazole-5-carboxylate
• Methyl 2-amino-4-(2-chlorophenyl)thiazole-5-carboxylate
• 4-(4-CHLORO-PHENYL)-THIAZOLE
• 4-(4-CHLOROPHENYL)-3-METHYL-2-(4-([(5-METHYLISOXAZOL-3-YL)AMINO]SULFONYL)ANILINO)-1,3-THIAZOL-3-IUM BROMIDE
• 1-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]-3-PHENYL-1H-PYRAZOL-5-AMINE
• 2-AMINO-4-(4'-CHLORO-3'-METHYL)PHENYLTHIAZOLE
• 1-(4-(4-CHLOROPHENYL))-2-THIAZOLYL-1'-TERT-BUTYL-3,3'-DIMETHYL-5-HYDROXY[4,5']-BIPYRAZOL
• 2-[[Amino(amino)methylene]amino]-4-(3-chlorophenyl)thiazole
• 4-(4-CHLOROPHENYL)-2-(2,4-DIFLUOROANILINO)-3-PROPYL-1,3-THIAZOL-3-IUM BROMIDE
• 4-(4-CHLOROPHENYL)-2-(2,4-DIFLUOROANILINO)-3-METHYL-1,3-THIAZOL-3-IUM BROMIDE