2-(4-FLUOROBENZYLAMINO)ETHANOL Chemical Properties

Boiling point:

95-98 °C(Press: 3 Torr)

Density 

1.1358 g/cm3

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Low-Melting Solid

pka

14.75±0.10(Predicted)

color 

White to Off-White

CAS DataBase Reference

22116-33-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

HazardClass 

IRRITANT

2-(4-FLUOROBENZYLAMINO)ETHANOL Usage And Synthesis

Uses

2-[(4-Fluorobenzyl)amino]ethanol is used in preparation of (Fluorobenzyl)aminomethylmorpholine salt and its application in preparation of mosapride citrate.

Uses

2-[(4-Fluorobenzyl)amino]ethanol is used in preparation of (Fluorobenzyl)aminomethylmorpholine salt and its application in preparation of mosapride citrate.

Application

2-(4-FLUOROBENZYLAMINO)ETHANOL can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

P-fluorobenzaldehyde (24.8 g, 0.2 mol) and 2-aminoethanol (15.3 g, 0.25 mol) were added to a reaction flask containing methanol (250 ml), heated to reflux, and kept at 65 ?? C for 4 h.The temperature was lowered, sodium borohydride (9.2 g 0.24 mol) was added, and the reaction was stirred, the reaction was completed, filtered, and concentrated.The fraction was collected to give 2-(4-fluorobenzylamino)ethanol as a colorless oily liquid (yield: 90.2%, purity 98.7%).

2-(4-FLUOROBENZYLAMINO)ETHANOL(22116-33-2)Related Product Information

• Fosaprepitant
• Mosapride
• Mosapride citrate
• Elgodipine
• 1-(4-FLUOROBENZOYL)-4-OXO-2-PYRROLIDINECARBOXYLIC ACID
• 4-(4-FLUOROBENZYL)MORPHOLINE
• (4-Fluorophenyl)(morpholino)methanone
• METHYL 1-(4-FLUOROBENZOYL)-4-HYDROXY-2-PYRROLIDINECARBOXYLATE
• 3-ACETYL-2-(4-FLUORO-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID
• 1-(4-FLUOROBENZOYL)-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID
• (4-FLUORO-BENZOYLAMINO)-ACETIC ACID
• 2-[(4-FLUOROBENZYL)AMINO]-1,1-BIS(4-FLUOROPHENYL)-1-ETHANOL
• 2-(4-FLUOROBENZOYL)AMINOPROPIONIC ACID
• ETHYL 2-[3-CYANO-6-(4-FLUOROPHENYL)-2-OXO-1(2H)-PYRIDINYL]ACETATE
• ETHYL 2-[(4-FLUOROBENZOYL)AMINO]ACETATE
• AKOS 10AC
• TIMTEC-BB SBB007410
• 1,1-BIS(4-CHLOROPHENYL)-2-[(4-FLUOROBENZYL)AMINO]-1-ETHANOL