9BETA,11ALPHA,15S-TRIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, TRIS (HYDROXYMETHYL)AMINOMETHANE SALT Chemical Properties

solubility 

Acetone: >5 mg/ml (from PGF2a THAM); Acetonitrile: >5 mg/ml (from PGF2a THAM); DMSO: >50 mg/ml (from PGF2a THAM); Ethanol: >50 mg/ml (from PGF2a THAM); Methanol: >100 mg/ml (from PGF2a THAM); PBS pH 7.2: >25 mg/ml (from PGF2a THAM)

form 

A crystalline solid

9BETA,11ALPHA,15S-TRIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, TRIS (HYDROXYMETHYL)AMINOMETHANE SALT Usage And Synthesis

Description

Prostaglandin F_2β (PGF_2β) (tromethamine salt) is a derivative of PGF_2β with increased water solubility. PGF_2β is the 9β-hydroxy stereoisomer of PGF2α . It is much less active than PGF_2α in antifertility and bronchoconstrictor activities. PGF_2β exhibits bronchodilating activity in guinea pigs and cats and antagonizes the bronchoconstrictor activity of PGF_2α.

Uses

(5R)-Dinoprost tromethamine (Prostaglandin F2β tromethamine) is a metabolite produced by the metabolism of arachidonic acid cyclooxygenase. (5R)-Dinoprost tromethamine induces dose-dependent release of hexosaccharide containing mucin[1][2].

References

[1] Lamont JT, et, al. Cysteamine and prostaglandin F2 beta stimulate rat gastric mucin release. Gastroenterology. 1983 Feb;84(2):306-13. PMID:6184259
[2] Jang Y, et, al. Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception. J Neuroinflammation. 2020 Jan 22;17(1):30. DOI:10.1186/s12974-020-1703-1

9BETA,11ALPHA,15S-TRIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, TRIS (HYDROXYMETHYL)AMINOMETHANE SALT(89847-02-9)Related Product Information

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