3'-N-ACETYLNEURAMIN-LACTOSE SODIUM SALT
3'-N-ACETYLNEURAMIN-LACTOSE SODIUM SALT Basic information
- Product Name:
- 3'-N-ACETYLNEURAMIN-LACTOSE SODIUM SALT
- Synonyms:
-
- NEU5AC-ALPHA2-3GAL-BETA1-4GLC
- MONOFUCOSYL, MONOSIALYLLACTOSE
- ALPHA-NEU5AC-[2->3]-BETA-D-GAL-[1->4]-D-GLC SODIUM SALT
- 3'-N-ACETYLNEURAMIN-LACTOSE SODIUM SALT
- 3'-SL
- 3'-SIALYLLACTOSE
- 3'-SIALYLLACTOSE SODIUM SALT
- II3NEUAC,I3FUC-LAC
- CAS:
- 128596-80-5
- MF:
- C23H40NNaO19
- MW:
- 657.55
- Mol File:
- Mol File
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3'-N-ACETYLNEURAMIN-LACTOSE SODIUM SALT Chemical Properties
- Melting point:
- >180oC (dec.)
- storage temp.
- −20°C
- solubility
- Methanol (Slightly, Heated), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- Cosmetics Ingredients Functions
- SKIN CONDITIONING - MISCELLANEOUS
- InChIKey
- PXGFDQDHNYOKKF-QQTUFLSENA-N
MSDS
- Language:English Provider:SigmaAldrich
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3'-N-ACETYLNEURAMIN-LACTOSE SODIUM SALT Usage And Synthesis
Uses
3''-Sialyllactose binds several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus.
in vivo
3'-Sialyllactose sodium (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1]. 3'-Sialyllactose sodium (500, 1000 and 2000 mg/kg; oral administration; once) induces no micronuclei in the bone marrow cells of mice[3]. 3'-Sialyllactose sodium (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs[3]. 3'-Sialyllactose sodium shows a lethal dose (LD50) above 20 g/kg bw, the highest dose tested[3].
| Animal Model: | 8-week-old male C57BL/6 mice with medial meniscus surgery[1] |
| Dosage: | 10, 50 and 100 mg/kg |
| Administration: | Oral gavage; 10-100 mg/kg three times a week; for 6 weeks |
| Result: | Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression. |
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