DIHYDROFOLIC ACID
DIHYDROFOLIC ACID Basic information
- Product Name:
- DIHYDROFOLIC ACID
- Synonyms:
-
- Folinic Acid EP Impurity G
- Folinic Acid EP Impurity G (7,8-Dihydrofolic Acid)
- (S)-2-(4-(((2-aMino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid
- 7,8-Dihydrofolic acid (DHF)
- Dihydrofolic acid 7,8-Dihydropteroyl-L-glutaMic acid
- N-[4-[[(2-aMino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-GlutaMic acid
- Folinic Acid Impurity G (7,8-Dihydrofolic Acid)
- 7,8-DIHYDROPTEROYL-L-GLUTAMIC ACID
- CAS:
- 4033-27-6
- MF:
- C19H21N7O6
- MW:
- 443.41
- Mol File:
- 4033-27-6.mol
DIHYDROFOLIC ACID Chemical Properties
- Melting point:
- >160°C (dec.)
- Density
- 1.69±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- 0.1 M NaOH: 10 mg/mL, slightly hazy, orange
- pka
- pKa 1.38(H2O t=25 I=0.10) (Occasionally);3.84(H2O t=25 I=0.10) (Occasionally)
- form
- Solid
- color
- Light Beige to Beige
- BRN
- 69017
- Stability:
- Air Sensitive, Hygroscopic, Temperature Sensitive
MSDS
- Language:English Provider:SigmaAldrich
DIHYDROFOLIC ACID Usage And Synthesis
Uses
antidote to methotrexate toxicity
Uses
Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).
Definition
ChEBI: Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a dihydrofolate(2-).
General Description
Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase.
Biochem/physiol Actions
Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).
Purification Methods
DHFA is best purified by suspending (1g mostly dissolved)) in ice-cold sodium ascorbate (300mL of 10% at pH 6.0, prepared by adjusting the pH of 30g of sodium ascorbate in 150mL of H2O by adding 1N NaOH dropwise using a gla
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DIHYDROFOLIC ACID(4033-27-6)Related Product Information
- Glycine
- Vitamin B12
- Folic acid
- 2-[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]aminopentanedioic acid
- Calcium levofolinate
- Calcium N5-methyltetrahydrofolate
- 5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid
- 10-Formylfolic Acid
- Folinic Acid IMpurity E
- 2-Amino-7-(chloromethyl)pteridin-4(1H)-one
- 2,4,5-Triamino-6-hydroxypyrimidine sulfate
- (S)-N-[4-[[(2-AMino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-glutaMic Acid
- 6-hydroxymethylpterin
- Folic Acid Impurity C
- 5-Methyl Tetrahedropteroic Acid (Mixture of DiastereoMers)
- folcysteine
- (2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6- yl]methylamino]benzoyl]amino]pentanedioic acid
- 6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE