Basic information Safety Supplier Related

DIHYDROFOLIC ACID

Basic information Safety Supplier Related

DIHYDROFOLIC ACID Basic information

Product Name:
DIHYDROFOLIC ACID
Synonyms:
  • Folinic Acid EP Impurity G
  • Folinic Acid EP Impurity G (7,8-Dihydrofolic Acid)
  • (S)-2-(4-(((2-aMino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid
  • 7,8-Dihydrofolic acid (DHF)
  • Dihydrofolic acid 7,8-Dihydropteroyl-L-glutaMic acid
  • N-[4-[[(2-aMino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-GlutaMic acid
  • Folinic Acid Impurity G (7,8-Dihydrofolic Acid)
  • 7,8-DIHYDROPTEROYL-L-GLUTAMIC ACID
CAS:
4033-27-6
MF:
C19H21N7O6
MW:
443.41
Mol File:
4033-27-6.mol
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DIHYDROFOLIC ACID Chemical Properties

Melting point:
>160°C (dec.)
Density 
1.69±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
0.1 M NaOH: 10 mg/mL, slightly hazy, orange
pka
pKa 1.38(H2O t=25 I=0.10) (Occasionally);3.84(H2O t=25 I=0.10) (Occasionally)
form 
Solid
color 
Light Beige to Beige
BRN 
69017
Stability:
Air Sensitive, Hygroscopic, Temperature Sensitive
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3

MSDS

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DIHYDROFOLIC ACID Usage And Synthesis

Uses

antidote to methotrexate toxicity

Uses

Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).

Definition

ChEBI: Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a dihydrofolate(2-).

General Description

Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase.

Biochem/physiol Actions

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Purification Methods

DHFA is best purified by suspending (1g mostly dissolved)) in ice-cold sodium ascorbate (300mL of 10% at pH 6.0, prepared by adjusting the pH of 30g of sodium ascorbate in 150mL of H2O by adding 1N NaOH dropwise using a gla

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