ANTI-STAT6 Chemical Properties

storage temp. 

-20°C

form 

buffered aqueous glycerol solution

biological source

rabbit

Safety Information

WGK Germany 

WGK 1

Storage Class

10 - Combustible liquids

ANTI-STAT6 Usage And Synthesis

Uses

These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .

General Description

Signal transducers and activators of transcription 6 (STAT6) belongs to the family of DNA binding proteins. It is mainly involved with Interleukin-4 (IL-4)-mediated gene expression. Src homology-2 domain (SH2) domain of STAT6 binds to docking sites of IL-4 receptor α to get tyrosine-phosphorylated by the receptor-associated janus kinase (JAK). This binding activates SATAT6 and it forms homodimer. Further, it translocates to the nucleus for adhering with the high affinity STAT-binding elements (SBE) of IL-4/IL-13.

Biological Activity

STAT6 is a human gene and is a member of the ST at family of transcription factors. It is mapped to human chromosome band 12q13. STAT6 has the same functional domain for both receptor coupling and dimerization. It is highly expressed in comparison with the other ST at proteins. STAT-6 silencing results in the reduction of HeLa cell programmed death and the expression of several important key factors related to programmed cell death. It is a highly sensitive and specific marker of solitary fibrous tumor (SFT). It can also be helpful in distinguishing tumor type from histologic mimics.