N1-ACETYLSPERMINE TRIHYDROCHLORIDE Chemical Properties

Melting point:

>256°C (dec.)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

BRN 

7052482

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

N1-ACETYLSPERMINE TRIHYDROCHLORIDE Usage And Synthesis

Description

N¹-Acetylspermine is a monoacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower K_m and higher V_max values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. N¹-Acetylspermine has been used to study the uptake of the anticancer polyamine analog bleomycin-A5 by the human carnitine transporter SLC22A16.

Uses

N1-Acetylspermine trihydrochloride has been used in a study to determine that the human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5.

References

[1] MUSTAPHA AOUIDA  Dindial R  Richard Poulin. The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5.[J]. The Journal of Biological Chemistry, 2010: 6275-6284. DOI: 10.1074/jbc.m109.046151

N1-ACETYLSPERMINE TRIHYDROCHLORIDE(77928-70-2)Related Product Information

• Spermidine
• N-(4-HYDROXYPHENYLPROPANOYL) SPERMINE TRIHYDROCHLORIDE
• N8-ACETYLSPERMIDINE DIHYDROCHLORIDE
• N1-ACETYLSPERMINE TRIHYDROCHLORIDE
• Spermidine trihydrochloride
• SPERMINEHYDROCHLORIDE
• 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
• Dipentene