Basic information Safety Supplier Related

N1-ACETYLSPERMINE TRIHYDROCHLORIDE

Basic information Safety Supplier Related

N1-ACETYLSPERMINE TRIHYDROCHLORIDE Basic information

Product Name:
N1-ACETYLSPERMINE TRIHYDROCHLORIDE
Synonyms:
  • N1-ACETYLSPERMINE TRIHYDROCHLORIDE
  • 1-ACETYLSPERMINE TRIHYDROCHLORIDE
  • N1-Acetylspermine (hydrochloride)
  • N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)acetamide trihydrochloride
CAS:
77928-70-2
MF:
C12H31Cl3N4O
MW:
353.76
Mol File:
77928-70-2.mol
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N1-ACETYLSPERMINE TRIHYDROCHLORIDE Chemical Properties

Melting point:
>256°C (dec.)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
BRN 
7052482
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3

MSDS

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N1-ACETYLSPERMINE TRIHYDROCHLORIDE Usage And Synthesis

Description

N1-Acetylspermine is a monoacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. N1-Acetylspermine has been used to study the uptake of the anticancer polyamine analog bleomycin-A5 by the human carnitine transporter SLC22A16.

Uses

N1-Acetylspermine trihydrochloride has been used in a study to determine that the human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5.

N1-ACETYLSPERMINE TRIHYDROCHLORIDESupplier

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