2-Chloro-4-methoxy-1-methylbenzene Chemical Properties

Boiling point:

76°C/2mm

Density 

1.105±0.06 g/cm3(Predicted)

Flash point:

76°C/2mm

refractive index 

1.5340

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow

CAS DataBase Reference

54788-38-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,F

HazardClass 

IRRITANT, FLAMMABLE

HS Code 

2909309090

2-Chloro-4-methoxy-1-methylbenzene Usage And Synthesis

Chemical Properties

Colorless liquid

Synthesis

3-Chloro-4-methylphenol (15 g, 0.11 mol), iodomethane (9.8 mL, 0.16 mol) and potassium carbonate (22 g, 0.16 mol) were mixed in DMF (200 mL). The reaction mixture was heated to 50 °C with continuous stirring for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction was quenched with 1N HCl aqueous solution. Subsequently, the aqueous phase was extracted with ether (Et2O), the organic phase was washed with brine, dried with anhydrous magnesium sulfate (MgSO4) and filtered. Finally, the solvent was removed by distillation under reduced pressure to give 16.4 g (100% yield) of 3-chloro-4-methylanisole.

References

[1] Patent: US2009/111800, 2009, A1. Location in patent: Page/Page column 27

2-Chloro-4-methoxy-1-methylbenzene(54788-38-4)Related Product Information

• tert-Butyldimethylsilyl chloride
• 2-Chloro-5-chloromethylpyridine
• 3,5-Dimethylanisole
• CHLOROMETHYLPHENYLSILANE
• Chloromethyltrimethylsilane
• 4-Methylanisole
• Difluorochloromethane
• Chloromethyl methyl ether
• 6-CHLOROPIPERONAL
• 4-Chloro-2-methoxy-5-methylaniline
• R(+)-IAA-94
• 6-CHLOROPIPERONYL ALCOHOL
• 2-CHLORO-3,4-DIMETHOXYCINNAMIC ACID
• 3-(2-CHLORO-3,4-DIMETHOXYPHENYL)PROP-2-ENOYL CHLORIDE
• Ethacrynic acid
• 2-Chloroveratraldehyde
• 6-CHLOROPIPERONYL CHLORIDE
• 1-CHLORO-4-METHOXY-2-METHYLBENZENE