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tert-Butyldimethylsilyl chloride

Basic information Introduction Safety Supplier Related

tert-Butyldimethylsilyl chloride Basic information

Product Name:
tert-Butyldimethylsilyl chloride
Synonyms:
  • t-butylchlorodimethyl-silan
  • SILANE TBM2
  • SILANE, CHLORO(1,1-DIMETHYLETHYL)DIMETHYL-
  • T-BUTYLDIMENHYLSILYL CHLORIDE
  • t-butyl dimethyl chlorsilane
  • T-BUTYLDIMETHYLCHLOROSILANE
  • T-BUTYLDIMETHYLSILYL CHLORIDE
  • TBDMSCI
CAS:
18162-48-6
MF:
C6H15ClSi
MW:
150.72
EINECS:
242-042-4
Product Categories:
  • Pharmaceutical intermediates
  • Organics
  • pharma material
  • organosilicon compounds
  • Miscellaneous Reagents
  • Alkyldimethylsilylation (GC Derivatizing Reagents)
  • FINE Chemical & INTERMEDIATES
  • blocks
  • BuildingBlocks
  • Coupling Reagent
  • N-Protecting Reagents
  • Protecting and Derivatizing Reagents
  • Protection and Derivatization
  • Silicon-Based
  • Blocking Agents
  • Chloro Silanes
  • Protective Agents
  • Silylating Agents
  • Analytical Chemistry
  • Biochemistry
  • GC Derivatizing Reagents
  • Monochlorosilanes
  • Nucleosides, Nucleotides & Related Reagents
  • Protecting Agents for Hydroxyl and Amino Groups
  • Protecting Agents, Phosphorylating Agents & Condensing Agents
  • Protection & Derivatization Reagents (for Synthesis)
  • Reagents for Oligosaccharide Synthesis
  • Si (Classes of Silicon Compounds)
  • Si-Cl Compounds
  • Silicon Compounds (for Synthesis)
  • Silylation (GC Derivatizing Reagents)
  • Synthetic Organic Chemistry
Mol File:
18162-48-6.mol
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tert-Butyldimethylsilyl chloride Chemical Properties

Melting point:
86-89 °C
Boiling point:
125 °C(lit.)
Density 
0.87 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.46
Flash point:
73 °F
storage temp. 
Store at 5°C
form 
Liquid
color 
Clear colorless
Specific Gravity
1.225
Water Solubility 
Soluble in chloroform and ethyl acetate. Insoluble in water.
Sensitive 
Moisture Sensitive
Hydrolytic Sensitivity
7: reacts slowly with moisture/water
Hydrolytic Sensitivity
8: reacts rapidly with moisture, water, protic solvents
BRN 
505999
InChIKey
BCNZYOJHNLTNEZ-UHFFFAOYSA-N
CAS DataBase Reference
18162-48-6(CAS DataBase Reference)
NIST Chemistry Reference
Silane, chloro(1,1-dimethylethyl)dimethyl-(18162-48-6)
EPA Substance Registry System
Silane, chloro(1,1-dimethylethyl)dimethyl- (18162-48-6)
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Safety Information

Hazard Codes 
C,F,T,Xn
Risk Statements 
22-35-40-34-10-19-11-67-65-63-48/20-20/21/22-45-23/24/25-37-36/37/38
Safety Statements 
26-36/37/39-46-62-45-25-16-28-27-33-29-53-36/37
RIDADR 
UN 2925 4.1/PG 2
WGK Germany 
2
RTECS 
VV2000000
10-21
Hazard Note 
Flammable/Corrosive/Moisture Sensitive
TSCA 
Yes
HazardClass 
4.1
PackingGroup 
III
HS Code 
29310095

MSDS

  • Language:English Provider:TBDMCS
  • Language:English Provider:SigmaAldrich
  • Language:English Provider:ACROS
  • Language:English Provider:ALFA
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tert-Butyldimethylsilyl chloride Usage And Synthesis

Introduction

Triethylchlorosilane is a clear, colourless to yellowish, pungent smelling, caustic and flammable liquid. It can be dissolved in non-protonating solvents without decomposition.
It may be used as silylating agent for dervatization of primary and secondary alcohols etc.. Also it may be used to protect allylic esters as silylketene acetal which is ore stable but less volatile derivates than trimethylchlorosilane.

Chemical Properties

White solid

Uses

Used to protect alcohols during organic synthesis.

Definition

ChEBI: A silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry ap lications.

Hazard

Moderately toxic.

Purification Methods

Fractionally distil it at atmospheric pressure. [Sommer & Tyler J Am Chem Soc 76 1030 1954, Corey & Venkateswarlu J Am Chem Soc 94 6190 1972, Beilstein 4 IV 4076.]

tert-Butyldimethylsilyl chlorideSupplier

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