FLURITHROMYCIN
FLURITHROMYCIN Basic information
- Product Name:
- FLURITHROMYCIN
- Synonyms:
-
- (8s)-8-fluoroerythromycina
- 8-fluoro-erythromyci
- 8-FluoroerythroMycin A
- 8-fluoroerythromycin
- antibioticp80206
- cl-932
- fluritromicina
- p80206
- CAS:
- 82664-20-8
- MF:
- C37H66FNO13
- MW:
- 751.92
- Product Categories:
-
- Carbohydrates & Derivatives
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 82664-20-8.mol
FLURITHROMYCIN Chemical Properties
- Melting point:
- >139°C (dec.)
- Boiling point:
- 814.6±65.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.94±0.70(Predicted)
- color
- White to Off-White
FLURITHROMYCIN Usage And Synthesis
Uses
A fluorinated derivative of Erythromycin (E649950). A macrolide antibiotic.
Definition
ChEBI: An erythromycin derivative that is erythromycin A in which the hydrogen attached to the carbon at position 8 (alpha to the ketone carbonyl group) has been replaced by a fluorine. It has been used (generally as the corresponding monoethyl s ccinate ester) as an antibacterial drug.
Pharmaceutical Applications
A semisynthetic derivative of erythromycin A, supplied for oral administration. It is stable at acid pH due to the presence of the fluorine atom at C-8 of the erythronolide A ring.
It is active against most streptococci (including Str. pneumoniae and Str. agalactiae; MIC50 0.03 mg/L), Mor. catarrhalis, N. gonorrhoeae (MIC50 0.04 mg/L), C. trachomatis (MIC 0.06– 0.125 mg/L), M. genitalium (MIC50 0.007 mg/L) and U. urealyticum (MIC50 0.03 mg/L). It has little or no activity against H. influenzae and M. hominis. Activity against anaerobes is similar to that of erythromycin A. It displays cross-resistance with erythromycin A.
A single 500 mg oral dose achieved a mean peak plasma concentration of 1.2–2 mg/L after 1–2 h. The apparent elimination half-life was 8 h and the volume of distribution 5.5 L/ kg. With repeated doses (500 mg orally every 8 h for 10 doses), plasma concentrations were 0.72 mg/L immediately before and 0.67 mg/L at 4 h after the last dose. Absorption is not significantly affected by food. After administration of a single 375 mg tablet of flurithromycin ethylsuccinate, the mean serum levels at 0.5 h were 0.43 ± 0.35 mg/L. The mean peak serum concentration (1.41 ± 0.49 mg/L) was achieved at 1 h. At 8 and 12 h, the serum levels were 0.14 (± 0.05) and 0.04 (± 0.04) mg/L, respectively. The apparent elimination half-life is 3.94 (± 1.42) h. The apparent half-life in artificial gastric juice was about 40 min.
It is generally well tolerated and has been used successfully for the treatment of lower respiratory tract infections. Availability is limited.
FLURITHROMYCIN Preparation Products And Raw materials
Raw materials
FLURITHROMYCINSupplier
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