METHYL 3-METHOXYPHENYLACETATE Chemical Properties

Boiling point:

80 °C

Density 

1.12

refractive index 

1.5130-1.5180

Flash point:

86-88°C/0.5mm

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow

Water Solubility 

Sparingly soluble in water.

CAS DataBase Reference

18927-05-4(CAS DataBase Reference)

Safety Information

HS Code 

2918999090

MSDS

• Language:English Provider:ALFA

METHYL 3-METHOXYPHENYLACETATE Usage And Synthesis

Uses

Methyl 3-methoxyphenylacetate is an important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.

Synthesis

Step 1. Synthesis of methyl 3-methoxyphenylacetate Trimethylmethylsilyl chloride (182 g, 1.68 mol) was slowly added dropwise to a solution of 3-methoxyphenylacetic acid (127 g, 0.77 mol) in methanol (1.0 L) over 1.1 hours. The reaction mixture was stirred at room temperature for 17.25 hours. Upon completion of the reaction, the mixture was concentrated under vacuum, dissolved in ethyl acetate and dried with anhydrous magnesium sulfate. Subsequently, the solution was concentrated under vacuum to afford the brown oily product methyl 3-methoxyphenylacetate (133 g, 97% yield). The structure of the product was confirmed by 1H NMR (CDCl3, 300 MHz): δ 7.24 (t, 1H, J = 7.5 Hz), 6.83 (m, 3H), 3.80 (s, 3H), 3.69 (s, 3H), 3.60 (s, 2H).

References

[1] Patent: US6077850, 2000, A

METHYL 3-METHOXYPHENYLACETATE(18927-05-4)Related Product Information

• METHYL 3-METHOXY-4-METHYLBENZOATE
• METHYL 3-METHOXY-2-NITROBENZOATE
• Methyl 3-methoxy-2-methylbenzoate
• Methyl 3-methyl-4-oxopentanoate
• 3-Methoxy-2,4,5-trifluorobenzoic acid
• 2,4,5-Trifluoro-3-methoxy-benzoic acid methyl ester
• Methyl 3-methyl-2-nitrobenzoate
• Methyl 3-methoxy-4-nitrobenzoate
• Methyl 3-Methyl-5-nitrobenzoate
• Methyl 3-methyl-4-nitrobenzoate
• Methyl 3-methyl-5-(trifluoromethyl)benzoate
• Methyl vanillate
• 2-[4-(HYDROXYMETHYL)-2-NITROPHENOXY]ACETIC ACID METHYL ESTER
• 3-Methoxyphenylacetic acid
• Methyl phenylacetate
• METHYL 4-METHOXYPHENYLACETATE
• methyl 2-(4-methoxyphenyl)propanoate
• METHYL 2-METHOXYPHENYLACETATE