Remibrutinib Chemical Properties

Boiling point:

634.8±55.0 °C(Predicted)

Density 

1.332±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 125 mg/mL (246.29 mM)

form 

Solid

pka

11.67±0.70(Predicted)

color 

White to off-white

InChIKey

CUABMPOJOBCXJI-UHFFFAOYSA-N

SMILES

C(NC1=CC(F)=CC(C2C(OCCN(C)C(=O)C=C)=C(N)N=CN=2)=C1C)(=O)C1=CC=C(C2CC2)C=C1F

Remibrutinib Usage And Synthesis

Description

Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC₅₀ value of 1 nM. Remibrutinib inhibits BTK activity with an IC₅₀ value of 0.023 μM in blood. Remibrutinib has the potential for Chronic urticaria (CU) treatment.

Chemical Properties

White to off-white Solid

Uses

Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood[1]. Remibrutinib has the potential for Chronic urticaria (CU) treatment[2].

References

[1] Daniela Angst, et al. Novel amino pyrimidine derivatives. Patent WO2015079417A1.
[2] Kolkhir P, et al. New treatments for chronic urticaria. Ann Allergy Asthma Immunol. 2019 Aug 23. DOI:10.1016/j.anai.2019.08.014