DMHCA Chemical Properties

Melting point:

189.5-190 °C

Boiling point:

525.6±23.0 °C(Predicted)

Density 

1.06±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMF: 1 mg/ml

form 

A solid

pka

15.03±0.70(Predicted)

color 

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(N(C)C)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C

DMHCA Usage And Synthesis

Uses

DMHCA has been used as LXR activator to tre at retinal endothelial cells in order to activate the sirtuin 1- liver X receptors (SIRT1-LXR) pathway.', 'It may be used as 3β-hydroxysterol-Δ24-reductase (DHCR24) inhibitor.

Biological Activity

N,N-dimethyl-3β-hydroxycholenamide (DHMCA) halts cholesterol biosynthesis by inhibiting 3β-hydroxysterol-Δ24-reductase (DHCR24) enzyme. It may serve as a therapeutic agent for treating atherosclerosis, age-related macular degeneration and diabetic retinopathy.', 'DMHCA (N,N-dimethyl-3β-hydroxycholenamide) is a synthetic oxysterol and is an agonist for liver X receptors (LXR). It promotes cholesterol transport, expression of adenosine triphosphate (ATP) binding cassette transporters. DMHCA suppresses the proinflammatory cytokines stimulation, induced by oxysterol.

in vivo