COPS6 ANTIBODY Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

COP9 signalosome complex subunit 6 belongs to the multisubunit COP9 signalsome which modulates protein ubiquitination to affect cellular processes such as cell-cycle progression and DNA damage repair. COPS6 is a putative oncogene that has been shown to be overexpressed in a significant percentage of colorectal cancers with poor prognosis. Mechanistically, research studies have shown that a signaling axis involving EGFR and ERK promotes tumor growth through the phosphorylation of COPS6, which indirectly facilitates downstream stabilization of β-catenin and enhancement of its transcriptional acitivity. Reasearch studies have also demonstrated that COPS6 contributes to tumorigenesis through the stabilization of other oncoproteins like c-Myc, MDM2 and E6AP.

References

[1] Wei, N. and Deng, X.W. (2003) Annu Rev Cell Dev Biol 19, 261-86.
[2] Verwoerd, C.D. et al. (1989) Rhinol Suppl 9, 87-96.
[3] Zhao, R. et al. (2011) J Clin Invest 121, 851-65.
[4] Gao, S. et al. (2015) Oncotarget 6, 28026-41.
[5] Chen, J. et al. (2014) Nat Commun 5, 5384.

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