CANDESARTAN-D4 Chemical Properties

Melting point:

151-157°C

storage temp. 

-20°C Freezer

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

form 

Solid

color 

White to Off-White

CANDESARTAN-D4 Usage And Synthesis

Description

Candesartan-d₄ is intended for use as an internal standard for the quantification of candesartan by GC- or LC-MS. Candesartan is an antagonist of the angiotensin II type 1 (AT₁) receptor (K_is = 0.17, 0.12, and 0.12 nM for human AT₁, rat AT_1A, and rat AT_1B recombinant receptors, respectively) and an active metabolite of the prodrug candesartan cilexitil (Item No. 10489). It is selective for AT₁ over AT₂ receptors (K_i = 26,500 nM for the human recombinant AT₂ receptor). It inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats following intravenous administration (ID₅₀ = 0.033 mg/kg). Formulations containing candesartan have been used in the treatment of hypertension and heart failure.

Chemical Properties

CANDESARTAN-D4 is White to Off-White Solid

Uses

Labelled Candesartan, an angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive.

Uses

CANDESARTAN-D4 is an angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive.

CANDESARTAN-D4(1346604-70-3)Related Product Information

• Octamethylcyclotetrasiloxane
• Candesartan