(R)-ADX-47273
(R)-ADX-47273 Basic information
- Product Name:
- (R)-ADX-47273
- Synonyms:
-
- (R)-ADX-47273
- (4-Fluorophenyl)[(3R)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]methanone
- Methanone, (4-fluorophenyl)[(3R)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-
- Inhibitor,inhibit,mGluR,(R)ADX47273,(R) ADX 47273,Metabotropic glutamate receptors
- (R)-ADX-47273, 10 mM in DMSO
- CAS:
- 851881-59-9
- MF:
- C20H17F2N3O2
- MW:
- 369.36
- Mol File:
- 851881-59-9.mol
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(R)-ADX-47273 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to off-white
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(R)-ADX-47273 Usage And Synthesis
Description
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation . mGluR5|168 nM (EC50)
(R)-ADX-47273 (ADX-47273 (5)) is a potent mGluR5 positive allosteric modulator with an EC50 for potentiation of 168 nM and a 9-fold shift of the glutamate response curve at 1 μM[1].
References
[1]. Engers DW, et al. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem. 2009 Apr;4(4):505-11.
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