22-(tert-Butoxy)-22-oxodocosanoic acid Chemical Properties

storage temp. 

Storage temp. 2-8°C

form 

powder

color 

White

InChI

InChI=1S/C26H50O4/c1-26(2,3)30-25(29)23-21-19-17-15-13-11-9-7-5-4-6-8-10-12-14-16-18-20-22-24(27)28/h4-23H2,1-3H3,(H,27,28)

InChIKey

OXPWLSZVTHVKQN-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)CCCCCCCCCCCCCCCCCCCCC(O)=O

Safety Information

HS Code 

2917198090

22-(tert-Butoxy)-22-oxodocosanoic acid Usage And Synthesis

Uses

22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t

IC 50

Non-cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

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