AZ304 Chemical Properties

Boiling point:

582.6±50.0 °C(Predicted)

Density 

1.270±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

pka

12.87±0.70(Predicted)

color 

White to off-white

Safety Information

HS Code 

2933998090

AZ304 Usage And Synthesis

Uses

AZ304 is potent dual BRAF inhibitor. Is a combination of MEK and B-raf inhibitors for treatment of cancer.

Biological Activity

AZ304 is a synthetic inhibitor targeting wild-type and V600E mutant BRAF with IC50 of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R with IC50 below 100 nM.

in vitro

AZ304 inhibited wild-type BRAF and CRAF, BRAF in vitro.

in vivo

In both RKO and Caco-2 tumor models, administration of AZ304 alone or in combination with Cetuximab resulted in antitumor activity without apparent toxic effects (regardless of BRAF mutation).

target

< td class="border-bottom: 1px dotted #ccc;padding: 5px;"> BRAF(V600E)
(Cell-free assay) < /tr>

Target	Value
p38 (Cell-free assay)	6 nM
CSF1R (Cell-free assay)	35 nM
38 nM
CRAF (Cell-free assay )	68 nM
WT BRAF (Cell-free assay)	79 nM