AZ304
AZ304 Basic information
- Product Name:
- AZ304
- Synonyms:
-
- AZ304;AZ-304;AZ 304
- AZ304
- Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl]-
- 3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide
- 3-(2-Cyano-2-propanyl)-N-{3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl}benzamide
- inhibit,AZ 304,Raf kinases,Autophagy,AZ304,Inhibitor,AZ-304,Raf
- CAS:
- 942507-42-8
- MF:
- C27H25N5O2
- MW:
- 451.52
- Product Categories:
-
- API
- Mol File:
- 942507-42-8.mol
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AZ304 Chemical Properties
- Boiling point:
- 582.6±50.0 °C(Predicted)
- Density
- 1.270±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 12.87±0.70(Predicted)
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AZ304 Usage And Synthesis
Uses
AZ304 is potent dual BRAF inhibitor. Is a combination of MEK and B-raf inhibitors for treatment of cancer.
Biological Activity
AZ304 is a synthetic inhibitor targeting wild-type and V600E mutant BRAF with IC50 of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R with IC50 below 100 nM.
in vitro
AZ304 inhibited wild-type BRAF and CRAF, BRAF in vitro.
in vivo
In both RKO and Caco-2 tumor models, administration of AZ304 alone or in combination with Cetuximab resulted in antitumor activity without apparent toxic effects (regardless of BRAF mutation).
target
| Target | Value |
| p38 (Cell-free assay) | 6 nM |
| CSF1R (Cell-free assay) | 35 nM |
| 38 nM | |
| CRAF (Cell-free assay ) | 68 nM |
| WT BRAF (Cell-free assay) | 79 nM | < /tr>
AZ304Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghaizehan biopharma technology co., Ltd.
- Tel
- 021-61350663 13052117465
- sales@zehanbiopharma.com
ShangHai Biochempartner Co.,Ltd
- Tel
- 17754423994 17754423994
- 2853530910@QQ.com
Shanghai Rechem science Co., Ltd.
- Tel
- 21-31433387 15618786686
- sales@rechemscience.com
Shanghai Chaolan Chemical Technology Center
- Tel
- QQ:65489617 15618227136
- info@SuperLan-chem.com