AZ304

Product Name: AZ304
CAS No.: 942507-42-8
Chemical Name: AZ304
Synonyms: AZ304;AZ304;AZ-304;AZ 304;inhibit,AZ 304,Raf kinases,Autophagy,AZ304,Inhibitor,AZ-304,Raf;3-(2-Cyano-2-propanyl)-N-{3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl}benzamide;3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide;Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl]-
CBNumber: CB44808617
Molecular Formula: C27H25N5O2
Formula Weight: 451.52
MOL File: 942507-42-8.mol

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AZ304 Property

Boiling point:: 582.6±50.0 °C(Predicted)
Density: 1.270±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 12.87±0.70(Predicted)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0064828
Product name: AZ304
Purity: 99.39%
Packaging: 25mg
Price: $150
Updated: 2021/12/16

Apolloscientific

Product number: BISN0220
Product name: 3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide
Packaging: 5mg
Price: $160
Updated: 2021/12/16

ChemScene

Product number: CS-0064828
Product name: AZ304
Purity: 99.39%
Packaging: 50mg
Price: $250
Updated: 2021/12/16

Apolloscientific

Product number: BISN0220
Product name: 3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide
Packaging: 10mg
Price: $261
Updated: 2021/12/16

ChemScene

Product number: CS-0064828
Product name: AZ304
Purity: 99.39%
Packaging: 100mg
Price: $450
Updated: 2021/12/16

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AZ304 Chemical Properties,Usage,Production

Uses

AZ304 is potent dual BRAF inhibitor. Is a combination of MEK and B-raf inhibitors for treatment of cancer.

Biological Activity

AZ304 is a synthetic inhibitor targeting wild-type and V600E mutant BRAF with IC50 of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R with IC50 below 100 nM.

in vitro

AZ304 inhibited wild-type BRAF and CRAF, BRAF in vitro.

in vivo

In both RKO and Caco-2 tumor models, administration of AZ304 alone or in combination with Cetuximab resulted in antitumor activity without apparent toxic effects (regardless of BRAF mutation).

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> BRAF(V600E)
(Cell-free assay) < /tr>

Target	Value
p38 (Cell-free assay)	6 nM
CSF1R (Cell-free assay)	35 nM
38 nM
CRAF (Cell-free assay )	68 nM
WT BRAF (Cell-free assay)	79 nM

AZ304 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZ304 Suppliers

China 38 India 1 United States 3 USA 1 Global 43

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 991
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2990
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9756
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29797
Advantage: 68

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9730
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: 0576-88813233 13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 2013
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 879
Advantage: 58

942507-42-8, AZ304Related Search:

AZ304;AZ-304;AZ 304

AZ304

Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl]-

3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide

3-(2-Cyano-2-propanyl)-N-{3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl}benzamide

inhibit,AZ 304,Raf kinases,Autophagy,AZ304,Inhibitor,AZ-304,Raf

942507-42-8

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