Basic information Safety Supplier Related

DBCO-PEG5-NHS ester

Basic information Safety Supplier Related

DBCO-PEG5-NHS ester Basic information

Product Name:
DBCO-PEG5-NHS ester
Synonyms:
  • 4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
CAS:
2144395-59-3
MF:
C36H43N3O11
MW:
693.74
Mol File:
2144395-59-3.mol
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DBCO-PEG5-NHS ester Chemical Properties

solubility 
Soluble in DMSO, DCM, DMF
form 
Oil
color 
Colorless to light yellow
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DBCO-PEG5-NHS ester Usage And Synthesis

Description

DBCO-PEG5-NHS Ester is a DBCO-containing PEG linker containing NHS ester that can react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. PEG5 spacer increases the water solubility of compounds in aqueous media. DBCO is commonly used for copper-free Click Chemistry reaction.

Biological Activity

DBCO-PEG5-NHS ester is a PROTAC linker, belonging to the PEG class and the Alkyl/ether class, for the synthesis of a series of PROTAC molecules. DBCO-PEG5-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

Alkyl/ether

PEGs

DBCO-PEG5-NHS esterSupplier

Shanghai Send Pharmaceutical Technology Co., Ltd.
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021-58088081 Q3252066219
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danping@shsendpharm.com
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
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0431-0431-80514535 19917294565
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et@chemextension.com
Borenpharm Co., Ltd
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027-65563561
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sales@borenpharm.com
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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info@efebio.com
Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
Email
psaitong@jm-bio.com
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DBCO-PEG5-NHS ester(2144395-59-3)Related Product Information