DBCO-PEG5-NHS ester
DBCO-PEG5-NHS ester Basic information
- Product Name:
- DBCO-PEG5-NHS ester
- Synonyms:
-
- 4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
- CAS:
- 2144395-59-3
- MF:
- C36H43N3O11
- MW:
- 693.74
- Mol File:
- 2144395-59-3.mol
DBCO-PEG5-NHS ester Chemical Properties
- solubility
- Soluble in DMSO, DCM, DMF
- form
- Oil
- color
- Colorless to light yellow
DBCO-PEG5-NHS ester Usage And Synthesis
Description
DBCO-PEG5-NHS Ester is a DBCO-containing PEG linker containing NHS ester that can react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. PEG5 spacer increases the water solubility of compounds in aqueous media. DBCO is commonly used for copper-free Click Chemistry reaction.
Biological Activity
DBCO-PEG5-NHS ester is a PROTAC linker, belonging to the PEG class and the Alkyl/ether class, for the synthesis of a series of PROTAC molecules. DBCO-PEG5-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| Alkyl/ether
| PEGs
|
DBCO-PEG5-NHS esterSupplier
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