t-Boc-Aminooxy-PEG1-amine Chemical Properties

Density 

1.070±0.06 g/cm3(Predicted)

solubility 

Soluble in Water, DMSO, DCM

pka

8.74±0.10(Predicted)

t-Boc-Aminooxy-PEG1-amine Usage And Synthesis

Description

t-Boc-Aminooxy-PEG1-amine is a PEG linker containing a Boc-protected aminooxy group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The protected aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde or ketone group to form a stable oxime linkage. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Uses

Boc-Aminooxy-PEG1-C2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

t-Boc-Aminooxy-PEG1-amine(1844894-82-1)Related Product Information

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