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BETAMETHASONE BENZOATE (200 MG)

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BETAMETHASONE BENZOATE (200 MG) Basic information

Product Name:
BETAMETHASONE BENZOATE (200 MG)
Synonyms:
  • BETAMETHASONE BENZOATE (200 MG)
  • 16-beta)-(11-beta
  • betamethasone17-benzoate
  • betamethasonebenzoate
  • pregna-1,4-diene-3,20-dione,17-(benzoyloxy)-9-fluoro-11,21-dihydroxy-16-methyl
  • BETAMETHASONE BENZOATE USP(CRM STANDARD)
  • (17R)-16β-Methyl-17α-(benzoyloxy)-11β,21-dihydroxy-9α-fluoropregna-1,4-diene-3,20-dione
  • 17-Benzoyloxy-9-fluoro-11β,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
CAS:
22298-29-9
MF:
C35H41FO8
MW:
608.6936432
EINECS:
2448979
Mol File:
22298-29-9.mol
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BETAMETHASONE BENZOATE (200 MG) Chemical Properties

Melting point:
225-228°
alpha 
D24 +63.5° (dioxane)
Boiling point:
641.0±55.0 °C(Predicted)
Density 
1.1732 (estimate)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
12.93±0.70(Predicted)
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Safety Information

RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
1
HS Code 
2937220000
Toxicity
LD50 scu-rat: 194 mg/kg TXAPA9 8,250,66
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BETAMETHASONE BENZOATE (200 MG) Usage And Synthesis

Originator

Benisone,Warner Lambert,US,1973

Uses

BETAMETHASONE BENZOATE (200 MG) is an analog of Betamethasone (B327000), a glucocorticoid used as an anti-inflammatory agent.

Definition

ChEBI: Betamethasone benzoate is a 21-hydroxy steroid.

Manufacturing Process

A mixture of 50 g of betamethasone, 50 cc of dimethylformamide, 50 cc of methyl orthobenzoate and 1.5 g of p-toluenesulfonic acid is heated for 24 hours on oil bath at 105°C while a slow stream of nitrogen is passed through the mixture and the methanol produced as a byproduct of the reaction is distilled off. After addition of 2 cc of pyridine to neutralize the acid catalyst the solvent and the excess of methyl orthobenzoate are almost completely eliminated under vacuum at moderate temperature. The residue is chromatographed on a column of 1,500 g of neutral aluminum oxide. By elution with ether-petroleum ether 30 g of a crystalline mixture are obtained consisting of the epimeric mixture of 17α,21-methyl orthobenzoates. This mixture is dissolved without further purification, in 600 cc of methanol and 240 cc of methanol and 240 cc of aqueous 2N oxalic acid are added to the solution. The reaction mixture is heated at 40°-50°C on water bath, then concentrated under vacuum, The residue, crystallized from acetone-ether, gives betamethasone 17-benzoate, MP 225°-231°C.

brand name

Uticort (Parke- Davis).

Therapeutic Function

Glucocorticoid

Safety Profile

Poison by subcutaneous route.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits toxic fumes of F-.

BETAMETHASONE BENZOATE (200 MG)Supplier

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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jkinfo@jkchemical.com
Sinopharm Chemical Reagent Co,Ltd.
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86-21-63210123
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sj_scrc@sinopharm.com
ChemStrong Scientific Co.,Ltd
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0755-0755-66853366 13670046396
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sales@chem-strong.com
Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973186 4009686088
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3193328036@qq.com
Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 13028896684
Email
sales@rrkchem.com
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BETAMETHASONE BENZOATE (200 MG)(22298-29-9)Related Product Information