d-Epigalbacin Chemical Properties

Boiling point:

460.6±45.0 °C(Predicted)

Density 

1.258±0.06 g/cm3(Predicted)

storage temp. 

4°C, protect from light

form 

Solid

color 

White to off-white

InChI

InChI=1S/C20H20O5/c1-11-12(2)20(14-4-6-16-18(8-14)24-10-22-16)25-19(11)13-3-5-15-17(7-13)23-9-21-15/h3-8,11-12,19-20H,9-10H2,1-2H3/t11-,12+,19-,20-/m0/s1

InChIKey

QFUXQRHAJWXPGP-YLYZPZNOSA-N

SMILES

O1[C@H](C2=CC=C3OCOC3=C2)[C@@H](C)[C@@H](C)[C@H]1C1=CC=C2OCOC2=C1

d-Epigalbacin Usage And Synthesis

Uses

(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively[1].

Biological Activity

(-)-Zuonin A (D-Epigalbacin), a natural lignin, is a potent and selective inhibitor of JNKs with IC50 values of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively.

in vitro

target

IC 50

JNK1: 1.7 μM (IC₅₀); JNK2: 2.9 μM (IC₅₀); JNK3: 1.74 μM (IC₅₀)

References

[1] Tamer S. Kaoud, et al. Manipulating JNK Signaling with (?)-zuonin A. ACS Chem Biol. 2012 Nov 16; 7(11): 1873–1883. DOI:10.1021/cb300261e

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