(RS)-2-AMINO-3-(4-CHLORO-3-HYDROXY-5-ISOXAZOLYL)PROPIONIC ACID Chemical Properties

Density 

1.66±0.1 g/cm3(Predicted)

storage temp. 

Store at RT

pka

2.26±0.10(Predicted)

form 

Powder

Water Solubility 

Soluble to 20 mM in water

(RS)-2-AMINO-3-(4-CHLORO-3-HYDROXY-5-ISOXAZOLYL)PROPIONIC ACID Usage And Synthesis

Uses

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor), a heterotetrameric transmembrane receptor, is found in various areas of the brain and mediates fast synaptic transmission in the central nervous system (1). Cl-HIBO (chloro-homoibotenic acid) is a subtype selective AMPA receptor agonist (2).

Biological Activity

Subtype-selective and strongly desensitising AMPA receptor agonist; selective for GluR1 and GluR2 subunit-containing receptors (EC 50 values are 4.7, 1.7, 2700 and 1300 μ M for rat recombinant homomeric GluR1, 2, 3 and 4 receptors respectively).